Mechanisms by Which Dendritic Cells Present Tumor Microparticle Antigens to CD8+ T Cells
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DOI: 10.1158/2326-6066.cir-17-0716
Abstract: Tumor-derived microparticles activate a lysosomal pathway enabling dendritic cell upregulation of costimulatory molecules and presentation of tumor antigens to CD+ T cells. Elucidation of this molecular pathway has clinical implications for the development of improved… read more here.
Keywords: activate lysosomal; tumor antigen; cd8 cells; mechanisms dendritic ... See more keywords