Alternative Mechanisms for DNA Engagement by BET Bromodomain-Containing Proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00157
Abstract: Epigenetic reader domains regulate chromatin structure and modulate gene expression through the recognition of post-translational modifications on histones. Recently, reader domains have also been found to harbor double-stranded (ds) DNA-binding activity, which is as functionally… read more here.
Keywords: dna engagement; bet; mechanisms dna; bet bromodomain ... See more keywords
Mechanisms of DNA opening revealed in AAA+ transcription complex structures
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DOI: 10.1126/sciadv.add3479
Abstract: Gene transcription is carried out by RNA polymerase (RNAP) and requires the conversion of the initial closed promoter complex, where DNA is double stranded, to a transcription-competent open promoter complex, where DNA is opened up.… read more here.
Keywords: complex structures; transcription; opening revealed; mechanisms dna ... See more keywords
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
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DOI: 10.15252/embr.202154217
Abstract: Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity during… read more here.
Keywords: damage mediated; damage; dna damage; mechanisms dna ... See more keywords
Mechanisms of DNA Methyltransferase Recruitment in Mammals
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DOI: 10.3390/genes9120617
Abstract: DNA methylation is an essential epigenetic mark in mammals. The proper distribution of this mark depends on accurate deposition and maintenance mechanisms, and underpins its functional role. This, in turn, depends on the precise recruitment… read more here.
Keywords: mechanisms dna; methyltransferase recruitment; recruitment; recruitment mammals ... See more keywords
Targeting Mechanisms of the DNA Damage Response (DDR) and DNA Repair by Natural Compounds to Improve cAT-Triggered Tumor Cell Death
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27113567
Abstract: Recently, we identified secalonic acid F (SA), 5-epi-nakijiquinone Q (NQ) and 5-epi-ilimaquinone (IQ) as natural compounds (NC) affecting mechanisms of the DNA damage response (DDR). Here, we further characterized their effects on DDR, DNA repair… read more here.
Keywords: dna repair; dna; natural compounds; mechanisms dna ... See more keywords