Elucidating molecular mechanisms of functional conformational changes of proteins via Markov state models.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2020.10.005
Abstract: Functional conformational changes of proteins can facilitate numerous biological events in cells. The Markov state model (MSM) built from molecular dynamics simulations provide a powerful approach to study them. We here introduce a protocol that… read more here.
Keywords: mechanisms functional; markov state; functional conformational; changes proteins ... See more keywords
MAP2 phosphorylation: mechanisms, functional consequences, and emerging insights
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2025.1610371
Abstract: Microtubule-associated protein 2 (MAP2) is a key regulator of cytoskeletal dynamics and neuronal function. It stabilizes microtubules, shapes dendrites, influences synaptic plasticity, and regulates transportation and protein synthesis through its interactions with other proteins. MAP2… read more here.
Keywords: phosphorylation mechanisms; phosphorylation; functional consequences; consequences emerging ... See more keywords
ASTROGLIA: Molecular Mechanisms, Functional Roles, and Neurophysiological Implications in the Central Nervous System
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DOI: 10.3390/life15101505
Abstract: Astrocytes, the principal components of astroglia, play essential roles in maintaining neuronal and synaptic homeostasis in the central nervous system. By regulating extracellular levels of glutamate, potassium (K+), and calcium (Ca2+), they prevent excitotoxicity and… read more here.
Keywords: central nervous; nervous system; molecular mechanisms; astroglia molecular ... See more keywords