Structural mechanisms for gating and ion selectivity of the human polyamine transporter ATP13A2.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.10.002
Abstract: Mutations in ATP13A2, also known as PARK9, cause a rare monogenic form of juvenile-onset Parkinson's disease named Kufor-Rakeb syndrome and other neurodegenerative diseases. ATP13A2 encodes a neuroprotective P5B P-type ATPase highly enriched in the brain… read more here.
Keywords: gating ion; structural mechanisms; polyamine; ion ... See more keywords
Intrinsic mechanisms in the gating of resurgent Na+ currents
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.70173
Abstract: The resurgent component of the voltage-gated sodium current (INaR) is a depolarizing conductance, revealed on membrane hyperpolarizations following brief depolarizing voltage steps, which has been shown to contribute to regulating the firing properties of numerous… read more here.
Keywords: nav channels; gating resurgent; voltage; fast slow ... See more keywords