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   Articles with "mechanisms mediating" as a keyword



Mechanisms Mediating the Combined Toxicity of Paraquat and Maneb in SH-SY5Y Neuroblastoma Cells

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recommendations! Published in 2024 at "Chemical Research in Toxicology"

DOI: 10.1021/acs.chemrestox.3c00389

Abstract: Epidemiological and experimental studies have demonstrated that combined exposure to the pesticides paraquat (PQ) and maneb (MB) increases the risk of developing Parkinson’s disease. However, the mechanisms mediating the toxicity induced by combined exposure to… read more here.

Keywords: sy5y neuroblastoma; toxicity; mechanisms mediating; paraquat maneb ... See more keywords

Abstract B082: Clonal dynamics and molecular mechanisms mediating resistance to RAS inhibition

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.pancreatic25-b082

Abstract: RAS inhibitors (RASi) have the potential to change the clinical landscape for pancreatic ductal adenocarcinoma (PDAC) and improve patient survival. Nevertheless, clinical resistance is likely to reduce the long-term benefits of RASi, and combinations that… read more here.

Keywords: resistance ras; resistance; clonal dynamics; molecular mechanisms ... See more keywords

Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activit.

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recommendations! Published in 2022 at "Journal of Parkinson's disease"

DOI: 10.3233/jpd-223516

Abstract: BACKGROUND Various cellular pathways have been implicated in the transfer of disease-related proteins between cells, contributing to disease progression and neurodegeneration. However, the overall effects of protein transfer are still unclear. OBJECTIVE Here, we performed… read more here.

Keywords: transfer; extracellular vesicles; disease; molecular mechanisms ... See more keywords

Mechanisms mediating the impact of maternal obesity on offspring hypothalamic development and later function

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recommendations! Published in 2022 at "Frontiers in Endocrinology"

DOI: 10.3389/fendo.2022.1078955

Abstract: As obesity rates have risen around the world, so to have pregnancies complicated by maternal obesity. Obesity during pregnancy is not only associated with negative health outcomes for the mother and the baby during pregnancy… read more here.

Keywords: function; maternal obesity; development; obesity ... See more keywords