Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.7b00105
Abstract: An appropriate level of protein phosphorylation on tyrosine is essential for cells to react to extracellular stimuli and maintain cellular homeostasis. Faulty operation of signal pathways mediated by protein tyrosine phosphorylation causes numerous human diseases,… read more here.
Keywords: tyrosine phosphatases; regulatory mechanisms; protein tyrosine; therapeutic targeting ... See more keywords
Research on function and mechanisms of a novel small molecule WG449E for hypertrophic scar
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.16028
Abstract: Hypertrophic scars are complications of severe wound healing characterized by excessive fibrosis associated with aberrant function of fibroblasts. However, no available drugs can be utilized to effectively treat these scars. The transforming growth factor β… read more here.
Keywords: novel small; function mechanisms; function; scar ... See more keywords
Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.935536
Abstract: Cancer cells undergo metabolic adaptations to sustain their growth and proliferation under several stress conditions thereby displaying metabolic plasticity. Epigenetic modification is known to occur at the DNA, histone, and RNA level, which can alter… read more here.
Keywords: metabolism; connections metabolism; metabolism epigenetics; epigenetics mechanisms ... See more keywords
Mechanisms and Novel Therapeutic Approaches for Gynecologic Cancer
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DOI: 10.3390/biomedicines10051014
Abstract: The number of patients with gynecological cancers, such as ovarian and endometrial cancer, has been increasing worldwide [...]. read more here.
Keywords: novel therapeutic; gynecologic cancer; approaches gynecologic; therapeutic approaches ... See more keywords
Conserved Mechanisms, Novel Anatomies: The Developmental Basis of Fin Evolution and the Origin of Limbs
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DOI: 10.3390/d13080384
Abstract: The transformation of paired fins into tetrapod limbs is one of the most intensively scrutinized events in animal evolution. Early anatomical and embryological datasets identified distinctive morphological regions within the appendage and posed hypotheses about… read more here.
Keywords: fin evolution; evolution; novel anatomies; appendage ... See more keywords
Metabolic Syndrome: From Molecular Mechanisms to Novel Therapies
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221810038
Abstract: The metabolic syndrome (MetS) consists of a cluster of metabolic abnormalities including central obesity, insulin resistance, glucose intolerance, hypertension, and atherogenic dyslipidemia [...]. read more here.
Keywords: syndrome molecular; metabolic syndrome; molecular mechanisms; novel therapies ... See more keywords