Structural mechanisms of phospholipid activation of the human TPC2 channel
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.45222
Abstract: Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-activated, Na+ selective channel, in the ligand-bound and apo states. The apo… read more here.
Keywords: human tpc2; mechanisms phospholipid; phospholipid activation; structural mechanisms ... See more keywords