Mechanisms of physiological and pathological cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-018-0007-y
Abstract: Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth. Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual cardiomyocytes increase in size, and the heart develops hypertrophy to… read more here.
Keywords: cardiac hypertrophy; mechanisms physiological; heart; physiological pathological ... See more keywords
Molecular mechanisms and physiological importance of circadian rhythms
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-019-0179-2
Abstract: To accommodate daily recurring environmental changes, animals show cyclic variations in behaviour and physiology, which include prominent behavioural states such as sleep–wake cycles but also a host of less conspicuous oscillations in neurological, metabolic, endocrine,… read more here.
Keywords: molecular clocks; mechanisms physiological; circadian rhythms; physiology ... See more keywords
Molecular mechanisms and physiological relevance of RGK proteins in the heart
Sign Up to like & getrecommendations! Published in 2018 at "Acta Physiologica"
DOI: 10.1111/apha.13016
Abstract: The primary route of Ca2+ entry into cardiac myocytes is via 1,4‐dihydropyridine‐sensitive, voltage‐gated L‐type Ca2+ channels. Ca2+ influx through these channels influences duration of action potential and engages excitation‐contraction (EC) coupling in both the atria… read more here.
Keywords: mechanisms physiological; heart; rgk; physiological relevance ... See more keywords
Mechanisms and Physiological Implications of Cooperative Gating of Ion Channels Clusters.
Sign Up to like & getrecommendations! Published in 2021 at "Physiological reviews"
DOI: 10.1152/physrev.00022.2021
Abstract: Ion channels play a central role in the regulation of nearly every cellular process. Dating back to the classic 1952 Hodgkin-Huxley model of the generation of the action potential, ion channels have always been thought… read more here.
Keywords: gating ion; ion channels; mechanisms physiological; ion ... See more keywords
Molecular mechanisms and physiological functions of autophagy in kidney diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.974829
Abstract: Autophagy is a highly conserved cellular progress for the degradation of cytoplasmic contents including micromolecules, misfolded proteins, and damaged organelles that has recently captured attention in kidney diseases. Basal autophagy plays a pivotal role in… read more here.
Keywords: kidney diseases; kidney; molecular mechanisms; autophagy kidney ... See more keywords
Molecular Mechanisms and Physiological Changes behind Benign Tracheal and Subglottic Stenosis in Adults
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052421
Abstract: Laryngotracheal stenosis (LTS) is a complex and heterogeneous disease whose pathogenesis remains unclear. LTS is considered to be the result of aberrant wound-healing process that leads to fibrotic scarring, originating from different aetiology. Although iatrogenic… read more here.
Keywords: subglottic stenosis; molecular mechanisms; changes behind; mechanisms physiological ... See more keywords