Mechanisms of resistance to commercially relevant entomopathogenic bacteria.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in insect science"
DOI: 10.1016/j.cois.2019.03.007
Abstract: Bacteria represent the most commercially successful entomopathogenic microbial group, with most commercialized insecticides containing gram-positive bacteria in the Bacillaceae family. Resistance to entomopathogenic bacteria threatens sustainable agriculture, and information on the mechanisms and genes involved… read more here.
Keywords: resistance commercially; relevant entomopathogenic; mechanisms resistance; resistance ... See more keywords
Memories and mechanisms of resistance to the Atlantic slave trade: the Ekang Saga in West Central Africa's epic tale the Mvet
Sign Up to like & getrecommendations! Published in 2020 at "Journal of African Cultural Studies"
DOI: 10.1080/13696815.2018.1532283
Abstract: The exploration of African oral literature has cast new light on the history of the Atlantic slave trade. Working on diverse regions and from various sources, scholars have used folk materials for ... read more here.
Keywords: resistance atlantic; mechanisms resistance; slave trade; memories mechanisms ... See more keywords
The future of fibroblast growth factor receptor inhibitors and mechanisms of resistance for cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2023.2202814
Abstract: ABSTRACT Introduction Cholangiocarcinoma (CCA) is a rare cancer that arises from the biliary tract. Despite advances in multimodal treatment, patients with CCA have a poor prognosis. Molecular profiling of CCA has identified unique genetic aberrations… read more here.
Keywords: cca; cholangiocarcinoma; mechanisms resistance; resistance ... See more keywords
Multidrug-resistant Klebsiella pneumoniae: mechanisms of resistance including updated data for novel β-lactam-β-lactamase inhibitor combinations
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2021.1924674
Abstract: ABSTRACT Introduction: Multi-drug-resistant Klebsiella pneumoniae is currently one of the most pressing emerging issues in bacterial resistance. Treatment of K.pneumoniae infections is often problematic due to the lack of available therapeutic options, with a relevant… read more here.
Keywords: mechanisms resistance; pneumoniae; lactam lactamase; resistance ... See more keywords
Utility of the Ba/F3 cell system for exploring on‐target mechanisms of resistance to targeted therapies for lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15263
Abstract: Molecular targeted therapies are the standard of care for front‐line treatment of metastatic non‐small‐cell lung cancers (NSCLCs) harboring driver gene mutations. However, despite the initial dramatic responses, the emergence of acquired resistance is inevitable. Acquisition… read more here.
Keywords: cell; targeted therapies; mechanisms resistance; resistance ... See more keywords
Mechanisms of resistance to immune checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15497
Abstract: Immune checkpoint inhibitors (ICIs) are effective for various types of cancer, and their application has led to paradigm shifts in cancer treatment. While many patients can obtain clinical benefits from ICI treatment, a large number… read more here.
Keywords: cell; checkpoint inhibitors; immune checkpoint; mechanisms resistance ... See more keywords
Molecular Mechanisms of Acquired Resistance to MET Tyrosine Kinase Inhibitors in Patients with MET Exon 14–Mutant NSCLC
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-3608
Abstract: Purpose: Molecular mechanisms of acquired resistance to MET tyrosine kinase inhibitors (TKI) are poorly understood. We aimed to characterize the genomic mechanisms of resistance to type I and type II MET TKIs and their impact… read more here.
Keywords: molecular mechanisms; met exon; resistance met; mechanisms resistance ... See more keywords
Novel Mechanisms for Resistance to Targeted Therapy Identified through Machine Learning Approaches in 1167 RNA-Seq Drug Exposure Profiles in Lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-119639
Abstract: Introduction: Diffuse large B cell lymphoma (DLBCL) is a clinically heterogeneous disease. While roughly half of the patients respond well to standard R-CHOP therapy, the majority of the remainder succumb to their disease. While many… read more here.
Keywords: machine learning; mechanisms resistance; drug; resistance ... See more keywords
Potential mechanisms of resistance to venetoclax and strategies to circumvent it
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DOI: 10.1186/s12885-017-3383-5
Abstract: BackgroundVenetoclax (ABT-199), a first-in-class orally bioavailable BCL-2-selective inhibitor, was recently approved by the FDA for use in patients with 17p-deleted chronic lymphocytic leukemia who have received prior therapy. It is also being evaluated in numerous… read more here.
Keywords: venetoclax; mechanisms resistance; potential mechanisms; resistance ... See more keywords
Molecular mechanisms of resistance to kinase inhibitors in thyroid cancers.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0129
Abstract: Protein kinases play critical roles in cell survival, proliferation and motility. Their dysregulation is therefore a common feature in the pathogenesis of a number of solid tumors, including thyroid cancers. Inhibiting activated protein kinases has… read more here.
Keywords: thyroid cancers; molecular mechanisms; kinase; mechanisms resistance ... See more keywords
Mechanisms of resistance to osimertinib.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2019.08.30
Abstract: The introduction of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has significantly improved the prognosis of advanced non-small cell lung cancer (NSCLC) patients with EGFR mutations. The most common mechanism of acquired resistance to… read more here.
Keywords: mechanisms resistance; resistance; egfr tkis; egfr ... See more keywords