Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00025
Abstract: TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as inclusion bodies in the brain and spinal cord of patients with the… read more here.
Keywords: tdp; pathology; amyotrophic lateral; molecular mechanisms ... See more keywords
Mechanisms of TDP-43 Proteinopathy Onset and Propagation
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DOI: 10.3390/ijms22116004
Abstract: TDP-43 is an RNA-binding protein that has been robustly linked to the pathogenesis of a number of neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. While mutations in the TARDBP gene that codes for… read more here.
Keywords: pathogenesis; onset propagation; tdp proteinopathy; mechanisms tdp ... See more keywords