Cellular stress response mechanisms as therapeutic targets of ginsenosides
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21450
Abstract: Ginseng, one of the most widely used traditional herbal medicines and dietary supplements, has historically been recognized as a tonic herb and adaptogen that can enhance the body's tolerance to various adversities. Ginsenosides are a… read more here.
Keywords: mechanisms therapeutic; stress; cellular stress; response mechanisms ... See more keywords
Aging and age‐related diseases: from mechanisms to therapeutic strategies
Sign Up to like & getrecommendations! Published in 2021 at "Biogerontology"
DOI: 10.1007/s10522-021-09910-5
Abstract: Aging is a physiological process mediated by numerous biological and genetic pathways, which are directly linked to lifespan and are a driving force for all age-related diseases. Human life expectancy has greatly increased in the… read more here.
Keywords: diseases mechanisms; mechanisms therapeutic; aging age; age related ... See more keywords
Candida Biofilms: An Update on Developmental Mechanisms and Therapeutic Challenges
Sign Up to like & getrecommendations! Published in 2020 at "Mycopathologia"
DOI: 10.1007/s11046-020-00445-w
Abstract: Fungi of the genus Candida are important etiological agents of superficial and life-threatening infections in individuals with a compromised immune system. One of the main characteristics of Candida is its ability to form highly drug… read more here.
Keywords: developmental mechanisms; mechanisms therapeutic; candida biofilms; update developmental ... See more keywords
Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.04.002
Abstract: In the past two decades, significant advances have been made in the etiology of lipid disorders. Concomitantly, the discovery of liporegulatory functions of certain short-chain fatty acids has generated interest in their clinical applications. In… read more here.
Keywords: mechanisms therapeutic; phenylbutyric acid; butyric acid; molecular mechanisms ... See more keywords
Inflammation in gout: mechanisms and therapeutic targets
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2017.155
Abstract: The acute symptoms of gout are triggered by the inflammatory response to monosodium urate crystals, mediated principally by macrophages and neutrophils. Innate immune pathways are of key importance in the pathogenesis of gout, in particular… read more here.
Keywords: gout mechanisms; mechanisms therapeutic; therapeutic targets; inflammation gout ... See more keywords
Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.485
Abstract: Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA and histone modification enzymes at the metabolite level. Conversely, epigenetic mechanisms regulate… read more here.
Keywords: epigenetics metabolism; oncogenesis mechanisms; mechanisms therapeutic; metabolism ... See more keywords
Chromatin regulatory mechanisms and therapeutic opportunities in cancer
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0258-1
Abstract: Research over the past several decades has unmasked a major contribution of disrupted chromatin regulatory processes to human disease, particularly cancer. Advances in genome-wide technologies have highlighted frequent mutations in genes encoding chromatin-associated proteins, identified… read more here.
Keywords: mechanisms therapeutic; regulatory mechanisms; therapeutic opportunities; chromatin regulatory ... See more keywords
Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac057
Abstract: The human gut microbiota is the microbial ecosystem in the small and large intestines of humans. It has been naturally preserved and evolved to play an important role in the function of the gastrointestinal tract… read more here.
Keywords: microbiota; mechanisms therapeutic; gut microbiota; methodological challenges ... See more keywords
Airway remodeling in asthma: update on mechanisms and therapeutic approaches
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Pulmonary Medicine"
DOI: 10.1097/mcp.0000000000000441
Abstract: Purpose of review The term ‘airway remodeling’ reflects changes in the type, quantity, and nature of airway wall components and their organization. The purpose of this review is to look at recent publications on airway… read more here.
Keywords: asthma update; mechanisms therapeutic; therapeutic approaches; remodeling asthma ... See more keywords
From basic mechanisms to therapeutic perspectives in cluster headache
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Neurology"
DOI: 10.1097/wco.0000000000001055
Abstract: Purpose of review The pathophysiological understanding of cluster headache has evolved significantly over the past years. Although it is now well known that the trigeminovascular system, the parasympathetic system and the hypothalamus play important roles… read more here.
Keywords: headache; mechanisms therapeutic; therapeutic perspectives; cluster headache ... See more keywords
Mitochondrial function in the heart: the insight into mechanisms and therapeutic potentials
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14431
Abstract: Mitochondrial dysfunction is considered as a crucial contributory factor in cardiac pathology. This has highlighted the therapeutic potential of targeting mitochondria to prevent or treat cardiac disease. Mitochondrial dysfunction is associated with aberrant electron transport… read more here.
Keywords: mechanisms therapeutic; mitochondrial function; insight mechanisms; therapeutic potentials ... See more keywords