Alternative Lengthening of Telomeres in Pediatric Cancer: Mechanisms to Therapies
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DOI: 10.3389/fonc.2019.01518
Abstract: Achieving replicative immortality is a crucial step in tumorigenesis and requires both bypassing cell cycle checkpoints and the extension of telomeres, sequences that protect the distal ends of chromosomes during replication. In the majority of… read more here.
Keywords: alternative lengthening; telomeres pediatric; mechanisms therapies; pediatric cancer ... See more keywords
Osteoporosis: From Molecular Mechanisms to Therapies 2.0
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DOI: 10.3390/ijms21218005
Abstract: Osteoporosis is a common skeletal disorder, occurring as a result of an imbalance between bone resorption and bone formation, with bone breakdown exceeding bone building. Bone resorption inhibitors, e.g., bisphosphonates, have been designed to treat… read more here.
Keywords: osteoporosis molecular; bone; mechanisms therapies; molecular mechanisms ... See more keywords