Residue-specific binding mechanisms of Thioflavin T to a surface of flat β-sheets within a peptide self-assembly mimic.
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DOI: 10.1021/acs.biochem.0c00280
Abstract: Thioflavin T (ThT) is a popular fluorescent dye for detecting amyloid, a protein aggregate with a β-sheet-rich structure that causes many neurodegenerative diseases. Despite the dye's popularity, a detailed understanding of its molecular binding mechanism… read more here.
Keywords: specific binding; binding mechanisms; binding mechanism; tht ... See more keywords