Mechanistic analysis of solid–liquid flow during injection
Sign Up to like & getrecommendations! Published in 2019 at "Particuology"
DOI: 10.1016/j.partic.2018.05.008
Abstract: Direct injection of retinal cells into the eyes of patients is a new and better therapeutic method for cataract, but the challenge is that the survival rate of cells during injection is very low. In… read more here.
Keywords: retinal cells; solid liquid; injection; analysis solid ... See more keywords
Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00658
Abstract: Over one and a half million people die of tuberculosis (TB) each year. Multidrug-resistant TB infections are especially dangerous, and new drugs are needed to combat them. The high cost and complexity of drug development… read more here.
Keywords: acetyltransferase eis; discovery mechanistic; inhibitors acetyltransferase; mechanistic analysis ... See more keywords
Mechanistic Analysis of the Biosynthesis of the Aspartimidylated Graspetide Amycolimiditide.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c09004
Abstract: Several classes of ribosomally synthesized and post-translationally modified peptides (RiPPs) are composed of multiple macrocycles. The enzymes that assemble these macrocycles must surmount the challenge of installing a single specific set of linkages out of… read more here.
Keywords: biosynthesis; graspetide amycolimiditide; analysis biosynthesis; biosynthesis aspartimidylated ... See more keywords
Biochemical and mechanistic analysis of the cleavage of branched DNA by human ANKLE1.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad416
Abstract: ANKLE1 is a nuclease that provides a final opportunity to process unresolved junctions in DNA that would otherwise create chromosomal linkages blocking cell division. It is a GIY-YIG nuclease. We have expressed an active domain… read more here.
Keywords: cleavage; analysis cleavage; mechanistic analysis; human ankle1 ... See more keywords