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   Articles with "mechanistic analysis" as a keyword



Beyond the model organism—Mechanistic analysis of protein post‐translational modifications is ready for all challengers

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recommendations! Published in 2024 at "PROTEOMICS"

DOI: 10.1002/pmic.202300314

Abstract: A historic challenge for shotgun proteomics has been the requirement for high quality, simple, and nonredundant curated protein sequences in small .fasta text files. Due to the intrinsic informatic challenges and time required to assemble… read more here.

Keywords: mechanistic analysis; translational modifications; organism mechanistic; post translational ... See more keywords

Mechanistic analysis of solid–liquid flow during injection

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recommendations! Published in 2019 at "Particuology"

DOI: 10.1016/j.partic.2018.05.008

Abstract: Direct injection of retinal cells into the eyes of patients is a new and better therapeutic method for cataract, but the challenge is that the survival rate of cells during injection is very low. In… read more here.

Keywords: retinal cells; solid liquid; injection; analysis solid ... See more keywords

Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs.

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recommendations! Published in 2023 at "Biochemistry"

DOI: 10.1021/acs.biochem.2c00658

Abstract: Over one and a half million people die of tuberculosis (TB) each year. Multidrug-resistant TB infections are especially dangerous, and new drugs are needed to combat them. The high cost and complexity of drug development… read more here.

Keywords: acetyltransferase eis; discovery mechanistic; inhibitors acetyltransferase; mechanistic analysis ... See more keywords

Mechanistic Analysis of the Biosynthesis of the Aspartimidylated Graspetide Amycolimiditide.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c09004

Abstract: Several classes of ribosomally synthesized and post-translationally modified peptides (RiPPs) are composed of multiple macrocycles. The enzymes that assemble these macrocycles must surmount the challenge of installing a single specific set of linkages out of… read more here.

Keywords: biosynthesis; graspetide amycolimiditide; analysis biosynthesis; biosynthesis aspartimidylated ... See more keywords

Comparative investigation and mechanistic analysis of textured PMN-30PT ceramics using BaTiO3 and PbTiO3 templates.

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recommendations! Published in 2025 at "Dalton transactions"

DOI: 10.1039/d5dt01206f

Abstract: Homogeneous PbTiO3 (PT) templates are considered an ideal choice for textured lead-based piezoceramics. In order to further investigate the texture mechanism and topological microcrystal conversion of PT templates, a comparative investigation and mechanistic analysis were… read more here.

Keywords: mechanistic analysis; comparative investigation; pbtio3 templates; pbtio3 ... See more keywords

Structural and mechanistic analysis of Ca2+-dependent regulation of transglutaminase 2 activity using a Ca2+-bound intermediate state

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2407066121

Abstract: Significance Transglutaminase 2 (TG2) is a multifunctional enzyme implicated in a myriad of both physiologic and pathophysiologic conditions including the gluten-sensitive enteropathy celiac disease. It is widely known that TG2, like all transglutaminases, requires calcium… read more here.

Keywords: mechanistic analysis; ca2 dependent; transglutaminase; structural mechanistic ... See more keywords

Biochemical and mechanistic analysis of the cleavage of branched DNA by human ANKLE1.

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recommendations! Published in 2023 at "Nucleic acids research"

DOI: 10.1093/nar/gkad416

Abstract: ANKLE1 is a nuclease that provides a final opportunity to process unresolved junctions in DNA that would otherwise create chromosomal linkages blocking cell division. It is a GIY-YIG nuclease. We have expressed an active domain… read more here.

Keywords: cleavage; analysis cleavage; mechanistic analysis; human ankle1 ... See more keywords