Cholangiocyte death in ductopenic cholestatic cholangiopathies: Mechanistic basis and emerging therapeutic strategies
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.12.044
Abstract: ABSTRACT Among hepatic diseases, cholestatic ductopenic cholangiopathies are poorly studied, and they are rarely given the importance they deserve, especially considering their high incidence in clinical practice. Although cholestatic ductopenic cholangiopathies have different etiologies and… read more here.
Keywords: cholestatic cholangiopathies; death; cholangiocyte death; therapeutic strategies ... See more keywords
Structural and mechanistic basis of the inhibitory potency of selected 2-aminothiazole compounds on protein kinase CK2.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00587
Abstract: Selective inhibitors of protein kinase CK2 with significant cytotoxicity on tumor cells based on a 2-aminothiazole scaffold were described recently. Here, these studies are supplemented with representative CK2α/CK2α' complex struc-tures. They reveal that the 2-aminothiazole-based… read more here.
Keywords: kinase ck2; structural mechanistic; mechanistic basis; protein kinase ... See more keywords
Structural and Mechanistic Basis of an Oxepin-CoA Forming Isomerase in Bacterial Primary and Secondary Metabolism.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00742
Abstract: Numerous aromatic compounds are aerobically degraded in bacteria via the central intermediate phenylacetic acid (paa). In one of the key steps of this widespread catabolic pathway, 1,2-epoxyphenylacetyl-CoA is converted by PaaG into the heterocyclic oxepin-CoA.… read more here.
Keywords: structural mechanistic; oxepin coa; mechanistic basis; coa ... See more keywords
Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18464-y
Abstract: O-Acetylation of the capsular polysaccharide (CPS) of Neisseria meningitidis serogroup A (NmA) is critical for the induction of functional immune responses, making this modification mandatory for CPS-based anti-NmA vaccines. Using comprehensive NMR studies, we demonstrate… read more here.
Keywords: acetylation; capsule; structural mechanistic; mechanistic basis ... See more keywords
The mechanistic basis for higher-order interactions and non-additivity in competitive communities.
Sign Up to like & getrecommendations! Published in 2019 at "Ecology letters"
DOI: 10.1111/ele.13211
Abstract: Motivated by both analytical tractability and empirical practicality, community ecologists have long treated the species pair as the fundamental unit of study. This notwithstanding, the challenge of understanding more complex systems has repeatedly generated interest… read more here.
Keywords: order interactions; non additivity; higher order; mechanistic basis ... See more keywords
Understanding the mechanistic basis of adaptation of perennial Sarcocornia quinqueflora species to soil salinity.
Sign Up to like & getrecommendations! Published in 2021 at "Physiologia plantarum"
DOI: 10.1111/ppl.13413
Abstract: Succulent halophytes can be used as convenient models for understanding the mechanistic basis of plant adaptation to salt stress. In this work, the effects of salinity (0 - 1000 mM NaCl range) on growth, ion accumulation… read more here.
Keywords: understanding mechanistic; mechanistic basis; salinity; quinqueflora ... See more keywords
Structural and Mechanistic Basis for Anaerobic Ergothioneine Biosynthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.2210/pdb6h9a/pdb
Abstract: Ergothioneine is an emergent factor in cellular redox biochemistry in humans and pathogenic bacteria. Broad consensus has formed around the idea that ergothioneine protects cells against reactive oxygen species. The recent discovery that anaerobic microorganisms… read more here.
Keywords: anaerobic ergothioneine; basis anaerobic; structural mechanistic; basis ... See more keywords
Structural and Mechanistic Basis of an Oxepin-CoA Forming Isomerase in Bacterial Primary and Secondary Metabolism
Sign Up to like & getrecommendations! Published in 2019 at "ACS Chemical Biology"
DOI: 10.2210/pdb6sla/pdb
Abstract: Numerous aromatic compounds are aerobically degraded in bacteria via the central intermediate phenylacetic acid (paa). In one of the key steps of this widespread catabolic pathway, 1,2-epoxyphenylacetyl-CoA is converted by PaaG into the heterocyclic oxepin-CoA.… read more here.
Keywords: coa; oxepin coa; basis oxepin; structural mechanistic ... See more keywords
Mechanistic Basis for the Role of Phytochemicals in Inflammation-Associated Chronic Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030781
Abstract: Chronic inflammatory diseases occur in a large portion of the population and are associated with a poor diet. Key natural products found in fruits and vegetables may assist in lowering inflammation associated with chronic diseases… read more here.
Keywords: associated chronic; mechanistic basis; chronic diseases; inflammation associated ... See more keywords
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.62611
Abstract: Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has emerged as a central player in this process. Yet, we have limited… read more here.
Keywords: protein; structural mechanistic; mechanistic basis; emc ... See more keywords