Advancing therapies for viral infections using mechanistic computational models of the dynamic interplay between the virus and host immune response
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Virology"
DOI: 10.1016/j.coviro.2021.07.007
Abstract: The COVID-19 pandemic has highlighted a need for improved frameworks for drug discovery, repurposing, clinical trial design and therapy optimization and personalization. Mechanistic computational models can play an important role in developing these frameworks. We… read more here.
Keywords: viral infections; mechanistic computational; therapies viral; immune response ... See more keywords
Catalytic and stoichiometric flavanone oxidation mediated by nonheme oxoiron(iv) complexes as flavone synthase mimics: kinetic, mechanistic and computational studies.
Sign Up to like & getrecommendations! Published in 2018 at "Dalton transactions"
DOI: 10.1039/c8dt03519a
Abstract: The present study describes the first example of the stoichiometric and catalytic oxidation of flavanone by synthetic nonheme oxoiron(iv) complexes and their precursor iron(ii) complexes with m-CPBA as the terminal oxidant. These models, including detailed… read more here.
Keywords: flavone synthase; oxoiron complexes; kinetic mechanistic; mechanistic computational ... See more keywords
Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1012157
Abstract: The spread of cancer from organ to organ (metastasis) is responsible for the vast majority of cancer deaths; however, most current anti-cancer drugs are designed to arrest or reverse tumor growth without directly addressing disease… read more here.
Keywords: cancer; computational modeling; mechanistic computational; antibody ... See more keywords