A mechanistic continuum of nucleophilic aromatic substitution reactions with azole nucleophiles
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DOI: 10.1039/d5sc01856k
Abstract: Nucleophilic aromatic substitution (SNAr) is a broadly used method for generating structural complexity in pharmaceuticals. Although SNAr reactions were long assumed to be stepwise, recent kinetic isotope effect (KIE) studies have shown that many SNAr… read more here.
Keywords: nucleophilic aromatic; azole nucleophiles; snar reactions; continuum ... See more keywords