Systematic Evaluation of Mechanistic Data in Assessing In Utero Exposures to Trichloroethylene and Development of Congenital Heart Defects.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152427
Abstract: The hypothesis that in utero exposures to low levels of trichloroethylene (TCE) may increase the risk of congenital heart defects (CHDs) in offspring remains a subject of substantial controversy within the scientific community due primarily… read more here.
Keywords: study; mechanistic data; systematic evaluation; congenital heart ... See more keywords
Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Health Perspectives"
DOI: 10.1289/ehp4971
Abstract: Background: Identification of female reproductive toxicants is currently based largely on integrated epidemiological and in vivo toxicology data and, to a lesser degree, on mechanistic data. A uniform approach to systematically search, organize, integrate, and… read more here.
Keywords: key characteristics; female reproductive; reproductive toxicants; mechanistic data ... See more keywords