A simple mechanistic explanation for Barth syndrome and cardiolipin remodeling.
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DOI: 10.1002/jimd.12445
Abstract: Barth syndrome is a multisystem disorder caused by an abnormal metabolism of the mitochondrial lipid cardiolipin. In this review, we discuss physical properties, biosynthesis, membrane assembly, and function of cardiolipin. We hypothesize that cardiolipin reduces… read more here.
Keywords: mechanistic explanation; explanation barth; barth syndrome; cardiolipin ... See more keywords
“Looking Up” and “Looking Down”: On the Dual Character of Mechanistic Explanations
Sign Up to like & getrecommendations! Published in 2018 at "Journal for General Philosophy of Science"
DOI: 10.1007/s10838-018-9402-7
Abstract: Mechanistic explanation is at present the received view of scientific explanation. One of its central features is the idea that mechanistic explanations are both “downward looking” and “upward looking”: they explain by offering information about… read more here.
Keywords: explanation; mechanistic explanation; functional explanation; mechanistic explanations ... See more keywords