Mechanistic Insight on Autophagy Modulated Molecular Pathways in Cerebral Ischemic Injury: From Preclinical to Clinical Perspective
Sign Up to like & getrecommendations! Published in 2022 at "Neurochemical Research"
DOI: 10.1007/s11064-021-03500-0
Abstract: Cerebral ischemia is one of the most devastating brain injuries and a primary cause of acquired and persistent disability worldwide. Despite ongoing therapeutic interventions at both the experimental and clinical levels, options for stroke-related brain… read more here.
Keywords: injury; pathways cerebral; mechanistic insight; cerebral ischemic ... See more keywords
Mechanistic insight into the enhanced photocatalytic activity of single-atom Pt, Pd or Au-embedded g-C 3 N 4
Sign Up to like & getrecommendations! Published in 2018 at "Applied Surface Science"
DOI: 10.1016/j.apsusc.2017.10.120
Abstract: Abstract Single atoms of platinum (Pt), palladium (Pd) or gold (Au) trapped by two-dimensional graphitic carbon nitride (g-C 3 N 4 ) exhibit superior photocatalytic performance. However, the underlying mechanism of single-atom noble metal/g-C 3… read more here.
Keywords: atom; mechanistic insight; insight enhanced; surface ... See more keywords
Targeting SARS-CoV-2 main protease by teicoplanin: A mechanistic insight by docking, MM/GBSA and molecular dynamics simulation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131124
Abstract: First emerged in late December 2019, the outbreak of novel severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) pandemic has instigated public-health emergency around the globe. Till date there is no specific therapeutic agent for this… read more here.
Keywords: molecular dynamics; mechanistic insight; cov main; main protease ... See more keywords
Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.02.014
Abstract: With almost half of the world population living at risk, tropical infectious diseases cause millions of deaths every year in developing countries. Considering the lack of economic prospects for investment in this field, approaches aiming… read more here.
Keywords: tropical infectious; insight antiviral; mechanistic insight; infectious diseases ... See more keywords
MECHANISTIC INSIGHT INTO THE ROLE OF THE VON WILLEBRAND FACTOR-ANGIOPOIETIN-AXIS IN PULMONARY ARTERIOVENOUS MALFORMATIONS IN CHILDREN WITH A GLENN CIRCULATION
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)33669-1
Abstract: Infants that undergo a superior cavo-pulmonary connection (Glenn operation) frequently develop pulmonary arteriovenous malformations that cause cyanosis and clinical deterioration. The cause of abnormal pulmonary angiogenesis in these children is unknown but may be related… read more here.
Keywords: von willebrand; arteriovenous malformations; role von; mechanistic insight ... See more keywords
Mechanistic Insight Into the Application of Alumina-Supported Pd Catalysts for the Hydrogenation of Nitrobenzene to Aniline
Sign Up to like & getrecommendations! Published in 2022 at "Industrial & Engineering Chemistry Research"
DOI: 10.1021/acs.iecr.2c01134
Abstract: Two Pd/γ-Al2O3 catalysts are examined for the vapor phase hydrogenation of nitrobenzene over the temperature range of 60–200 °C. A 1 wt % catalyst is selected as a reference material that is diluted with γ-alumina… read more here.
Keywords: hydrogenation nitrobenzene; mechanistic insight; insight application; application alumina ... See more keywords
Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01818
Abstract: The pharmacologically privileged DHP derivatives were synthesized using the pragmatic multicomponent Hantzsch synthesis to screen the antidiabetic activity. Initially, the candidates were screened using an in vivo blood glucose test, where compound 8b showed the… read more here.
Keywords: dihydropyridines antidiabetic; mechanistic insight; insight synthesized; synthesized dihydropyridines ... See more keywords
Mechanistic Insight into Ultrafast Kinetics of Sodium Cointercalation in Few-Layer Graphitic Carbon.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c02177
Abstract: Fast-charging sodium ion batteries remain deeply challenged by the lack of suitable carbonaceous anodes that exhibit intercalation plateau with fast kinetics. Here we develop a few-layer graphitic carbon with nanoscale architecture, which enables shortened Na+… read more here.
Keywords: graphitic carbon; carbon; mechanistic insight; insight ultrafast ... See more keywords
Mechanistic Insight into the Catalytic Staudinger Ligation.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.8b04035
Abstract: Organophosphorus-catalyzed Staudinger ligation between carboxylic acids and azides in the presence of phenylsilane reductant produces amides. NMR-based mechanistic investigations revealed that the catalytic Staudinger ligation does not proceed via reduction of phosphine oxide but rather… read more here.
Keywords: catalytic staudinger; mechanistic insight; insight catalytic; ligation ... See more keywords
Mechanistic Insight into the Framework Methylation of H-ZSM-5 for Varying Methanol Loadings and Si/Al Ratios Using First-Principles Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2020 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c01454
Abstract: The methanol-to-hydrocarbon process is known to proceed autocatalytically in H-ZSM-5 after an induction period where framework methoxy species are formed. In this work, we provide mechanistic insight into the framework methylation within H-ZSM-5 at high… read more here.
Keywords: insight framework; mechanistic insight; molecular dynamics; methanol ... See more keywords
Formamide-Catalyzed Nucleophilic Substitutions: Mechanistic Insight and Rationalization of Catalytic Activity
Sign Up to like & getrecommendations! Published in 2020 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c03348
Abstract: Herein, detailed mechanistic investigations into formamide-catalyzed nucleophilic substitution (SN) of alcohols are reported. Alkoxyiminium chlorides and hexafluorophosphates were synthesized and c... read more here.
Keywords: catalyzed nucleophilic; mechanistic insight; formamide catalyzed; insight rationalization ... See more keywords