Mechanistic insights into the ROS-mediated inactivation of human aldehyde oxidase.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14669
Abstract: Human aldehyde oxidase (hAOX1) is a molybdoenzyme that oxidizes aldehydes and N-heterocyclic compounds, thereby generating hydrogen peroxide (H2 O2 ) and superoxide during turnover. hAOX1 has been shown previously to be inactivated under turnover conditions… read more here.
Keywords: aldehyde oxidase; insights ros; ros mediated; human aldehyde ... See more keywords
Mechanistic Insights and Rational Design of a Versatile Surface with Cells/Bacteria Recognition Capability via Orientated Fusion Peptides
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201801827
Abstract: Abstract Hospital‐acquired infection causes many deaths worldwide and calls for the urgent need for antibacterial biomaterials used in clinic that can selectively kill harmful bacteria. The present study rationally designs fusion peptides capable of undergoing… read more here.
Keywords: smart surface; surface; recognition; fusion peptides ... See more keywords
Mechanistic insights and implications of FOXO‐SNAI interplay
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200070
Abstract: Autophagy promotes both health and disease, depending on tissue types and genetic contexts, yet the regulatory mechanism remain incompletely understood. Our recent publication has uncovered a coherent FOXO‐SNAI feed‐forward loop in autophagy, which is evolutionarily… read more here.
Keywords: foxo snai; implications foxo; snai interplay; insights implications ... See more keywords
Mechanistic Insights into the Activities of Major Families of Enzymes in Bacterial Peptidoglycan Assembly and Breakdown
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200693
Abstract: Serving as an exoskeletal scaffold, peptidoglycan is a polymeric macromolecule that is essential and conserved across all bacteria, yet is absent in mammalian cells; this has made bacterial peptidoglycan a well‐established excellent antibiotic target. In… read more here.
Keywords: activities major; bacterial peptidoglycan; assembly breakdown; peptidoglycan assembly ... See more keywords
Mechanistic Insights into Manganese (I)‐Catalyzed Chemoselective Hydroarylations of Alkynes: A Theoretical Study
Sign Up to like & getrecommendations! Published in 2018 at "ChemCatChem"
DOI: 10.1002/cctc.201801301
Abstract: Density functional theory calculations were employed to elucidate the mechanism of Mn‐catalyzed chemoselective hydroarylation reactions. The Mn‐catalyzed [4+2] annulation undergoes a reaction pathway involving sequential imine‐directed C−H bond cleavage, alkyne insertion into the Mn−C bond,… read more here.
Keywords: catalyzed chemoselective; manganese catalyzed; study; alkyne insertion ... See more keywords
Mechanistic Insights for Nitromethane Activation into Reactive Nitrogenating Reagents
Sign Up to like & getrecommendations! Published in 2021 at "ChemCatChem"
DOI: 10.1002/cctc.202100086
Abstract: Recently, it was found that nitromethane (CH3NO2) can be activated into a useful nitrogenating reagent for the synthesis of amide and nitrile compounds. In this work, the mechanisms of CH3NO2 activation are explored in detail… read more here.
Keywords: insights nitromethane; nitromethane activation; activation; reactive nitrogenating ... See more keywords
Mechanistic Insights into the Unique Role of Copper in CO2 Electroreduction Reactions.
Sign Up to like & getrecommendations! Published in 2017 at "ChemSusChem"
DOI: 10.1002/cssc.201601144
Abstract: Cu demonstrates a unique capability towards CO2 electroreduction that can close the anthropogenic carbon cycle; however, its reaction mechanism remains elusive, owing to the obscurity of the solid-liquid interface on Cu surfaces where electrochemical reactions… read more here.
Keywords: unique role; insights unique; electroreduction; co2 electroreduction ... See more keywords
Mechanistic insights on nsSNPs on binding site of renin and cytochrome P450 proteins: A computational perceptual study for pharmacogenomics evaluation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30069
Abstract: Past several decades, therapeutic investigations lead to the discovery of numerous antihypertensive drugs. Although it has been proved for their potency, altered efficacy is common norms in several conditions due to genetic variations. Cytochrome P450… read more here.
Keywords: study; drug; drug molecules; cytochrome p450 ... See more keywords
Mechanistic insights into the role of vitamin D and computational identification of potential lead compounds for Parkinson's disease
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30379
Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects dopaminergic neurons in the midbrain. A recent study suggests that Orphan Nuclear Receptor 1 (NURR1) impairment may contribute to PD pathogenesis. Our study… read more here.
Keywords: role vitamin; disease; parkinson disease; insights role ... See more keywords
Mechanistic insights into the role of actinobacteria as potential biocontrol candidates against fungal phytopathogens.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of basic microbiology"
DOI: 10.1002/jobm.202300027
Abstract: Worldwide mounting demand for better food production to nurture exasperating population emphasizes on reduced crop losses. The incidence of pathogens into the agricultural fields has tend to dwindle plethora of cereal, vegetable, and other fodder… read more here.
Keywords: role actinobacteria; biocontrol; role; insights role ... See more keywords
Mechanistic Insights into a Sustainable Mechanochemical Synthesis of Ettringite
Sign Up to like & getrecommendations! Published in 2019 at "ChemistryOpen"
DOI: 10.1002/open.201900215
Abstract: Abstract Mechanochemistry offers an environmentally benign and facile synthesis method for a variety of cement paste constituents. In addition, these methods can be used to selectively tune the properties of cement components. The mineral ettringite… read more here.
Keywords: insights sustainable; synthesis; mechanochemical synthesis; sustainable mechanochemical ... See more keywords