A computational framework to integrate high-throughput ‘-omics’ datasets for the identification of potential mechanistic links
Sign Up to like & getrecommendations! Published in 2018 at "Nature Protocols"
DOI: 10.1038/s41596-018-0064-z
Abstract: We recently presented a three-pronged association study that integrated human intestinal microbiome data derived from shotgun-based sequencing with untargeted serum metabolome data and measures of host physiology. Metabolome and microbiome data are high dimensional, posing… read more here.
Keywords: mechanistic links; microbiome; physiology; potential mechanistic ... See more keywords
Childhood adversity and mechanistic links to hypertension risk in adulthood
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14576
Abstract: Adverse childhood experiences (ACEs), defined as traumatic events in childhood that range from various forms of abuse to household challenges and dysfunction, have devastating consequences on adult health. Epidemiological studies in humans and animal models… read more here.
Keywords: mechanistic links; risk; hypertension risk; childhood adversity ... See more keywords
Lipid Exchangers: Cellular Functions and Mechanistic Links With Phosphoinositide Metabolism
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00663
Abstract: Lipids are amphiphilic molecules that self-assemble to form biological membranes. Thousands of lipid species coexist in the cell and, once combined, define organelle identity. Due to recent progress in lipidomic analysis, we now know how… read more here.
Keywords: mechanistic links; exchangers cellular; metabolism; functions mechanistic ... See more keywords