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   Articles with "mechanistic model" as a keyword



Predictive mechanistic model for separation of monoclonal antibody, fab fragment, and aggregate species on multimodal chromatography

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recommendations! Published in 2025 at "Biotechnology Progress"

DOI: 10.1002/btpr.70022

Abstract: The specific selectivities offered by multimodal ligands drive the increased application of multimodal chromatography in the purification of complex new “multispecific” antibodies, which requires improved understanding of the protein‐multimodal ligand interaction mechanism. In the present… read more here.

Keywords: monoclonal antibody; fab fragment; mab1 fab; model ... See more keywords

Importance of Initial Concentration of Factor VIII in a Mechanistic Model of In Vitro Coagulation

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recommendations! Published in 2018 at "Acta Biotheoretica"

DOI: 10.1007/s10441-018-9329-8

Abstract: This computational study generates a hypothesis for the coagulation protein whose initial concentration greatly influences the course of coagulation. Many clinical malignancies of blood coagulation arise due to abnormal initial concentrations of coagulation factors. Sensitivity… read more here.

Keywords: coagulation; mechanistic model; model; initial concentration ... See more keywords

Development of a mechanistic model for sliding bubbles growth prediction in subcooled boiling flow

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recommendations! Published in 2018 at "Applied Thermal Engineering"

DOI: 10.1016/j.applthermaleng.2018.04.096

Abstract: Abstract A new mechanistic model for predicting the growth of sliding bubbles in subcooled boiling flow has been developed. The basis of this model is the assumption that the fundamental heat transfer mechanisms acting on… read more here.

Keywords: bubble growth; mechanistic model; model; subcooled boiling ... See more keywords

A mechanistic model of erythroblast growth inhibition providing a framework for optimisation of cell therapy manufacturing

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recommendations! Published in 2018 at "Biochemical Engineering Journal"

DOI: 10.1016/j.bej.2018.01.033

Abstract: Abstract Manufacture of Red Blood Cell based products in vitro requires highly efficient erythroblast culture for economic viability. It has previously been shown that efficiency of erythroblast culture in scalable bioreactors is not primarily limited… read more here.

Keywords: cell; medium; mechanistic model; inhibition ... See more keywords

A comprehensive mechanistic model for simulating algal-bacterial growth dynamics in photobioreactors.

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recommendations! Published in 2018 at "Bioresource technology"

DOI: 10.1016/j.biortech.2017.09.093

Abstract: A comprehensive mechanistic model with state of the art understanding and assumptions is presented to simulate major processes in a photobioreactor for describing the algal-bacterial growth dynamics. The model includes a total of 37 state… read more here.

Keywords: comprehensive mechanistic; growth dynamics; mechanistic model; algal bacterial ... See more keywords

Mechanistic model for Francis turbines in OpenModelica

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recommendations! Published in 2018 at "IFAC-PapersOnLine"

DOI: 10.1016/j.ifacol.2018.03.018

Abstract: Abstract Often, simulation tools use an empirical turbine model, typically based on look-up tables for turbine efficiency. Such look-up tables can be based on dimensionless hill charts which again require experimental data, or can be… read more here.

Keywords: turbine; mechanistic model; model; design algorithm ... See more keywords

Predicting the ductile failure of Al5083-H116 specimens with a mechanistic model and no free fitting parameters

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recommendations! Published in 2017 at "International Journal of Solids and Structures"

DOI: 10.1016/j.ijsolstr.2017.02.025

Abstract: Abstract A mechanistic model that does not depend on free fitting parameters was developed for predicting the ductile failure of Al 5083-H116. The model takes three inputs: (1) the large deformation constitutive response of the… read more here.

Keywords: ductile failure; mechanistic model; free fitting; model ... See more keywords

Toward the General Mechanistic Model of Liquid Chromatographic Retention.

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recommendations! Published in 2022 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c02034

Abstract: Large datasets of chromatographic retention times are relatively easy to collect. This statement is particularly true when mixtures of compounds are analyzed under a series of gradient conditions using chromatographic techniques coupled with mass spectrometry… read more here.

Keywords: retention; chromatographic retention; analyte specific; toward general ... See more keywords

Mechanistic Model To Predict Hydrate Deposition under Stratified Flow Conditions

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recommendations! Published in 2019 at "Energy & Fuels"

DOI: 10.1021/acs.energyfuels.9b01624

Abstract: Gas hydrate formation in pipelines is considered as a serious flow assurance threat to oil and gas production. The severity can be realized from its rapid tendency to form plugs and impede production. The assessment… read more here.

Keywords: mechanistic model; stratified flow; deposition; model ... See more keywords

Mechanistic Model for the Hsp90-Driven Opening of Human Argonaute

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recommendations! Published in 2020 at "Journal of Chemical Information and Modeling"

DOI: 10.1021/acs.jcim.0c00053

Abstract: The assembly of RNA-induced silencing complex (RISC) is a key process in small RNA-mediated gene silencing. Loading of small RNAs into Argonaute (Ago), the key player protein in the process, has been shown to depend… read more here.

Keywords: hsp90 driven; hsp90; hago2; mechanistic model ... See more keywords

A refined mechanistic model for swelling kinetics of starch granules.

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recommendations! Published in 2025 at "Soft matter"

DOI: 10.1039/d4sm00980k

Abstract: This paper investigates the gelatinization of individual starch granules using numerical simulations, validated against experimental microscopy data from a ParCS apparatus. We show that the dynamics of starch-granule swelling can be captured by a diffusion… read more here.

Keywords: starch granules; swelling data; refined mechanistic; mechanistic model ... See more keywords