Mechanistic modeling and simulation of a complex low and high loading elution behavior of a polypeptide in cation exchange chromatography.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200098
Abstract: The mechanistic modeling of preparative liquid chromatography is still a challenging task. Non-ideal thermodynamic conditions may require activity coefficients for the mechanistic description of preparative chromatography. In this work, a chromatographic cation exchange step with… read more here.
Keywords: elution behavior; behavior; mechanistic modeling; cation exchange ... See more keywords
Mechanistic modeling of cation exchange chromatography scale-up considering packing inhomogeneities.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of separation science"
DOI: 10.1002/jssc.202300031
Abstract: In process development and characterization, the scale-up of chromatographic steps is a crucial part and brings a number of challenges. Usually, scale-down models are used to represent the process step, and constant column properties are… read more here.
Keywords: scale; exchange chromatography; mechanistic modeling; cation exchange ... See more keywords
Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2021.05.022
Abstract: Genome-scale mechanistic models of pathways are gaining importance for genomic data interpretation because they provide a natural link between genotype measurements (transcriptomics or genomics data) and the phenotype of the cell (its functional behavior). Moreover,… read more here.
Keywords: genome scale; cytoscape; bioconductor; mechanistic modeling ... See more keywords
Toward mechanistic modeling and rational engineering of plant respiration
Sign Up to like & getrecommendations! Published in 2023 at "Plant Physiology"
DOI: 10.1093/plphys/kiad054
Abstract: Abstract Plant respiration not only provides energy to support all cellular processes, including biomass production, but also plays a major role in the global carbon cycle. Therefore, modulation of plant respiration can be used to… read more here.
Keywords: rational engineering; plant respiration; mechanistic modeling; plant ... See more keywords
Mechanistic modeling of persistent organic pollutant exposure among indigenous Arctic populations: motivations, challenges, and benefits
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Reviews"
DOI: 10.1139/er-2017-0010
Abstract: Indigenous Arctic populations experience elevated exposures to many environmental contaminants compared with groups residing in southern Canada. This is largely due to consumption of traditional foods, some of which (ringed seals, beluga whales, narwhals, etc.)… read more here.
Keywords: arctic populations; indigenous arctic; persistent organic; exposure ... See more keywords
Mechanistic Modeling of Wet Stirred Media Milling for Production of Drug Nanosuspensions.
Sign Up to like & getrecommendations! Published in 2020 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-020-01876-w
Abstract: Drug nanocrystals have been used for a wide range of drug delivery platforms in the pharmaceutical industry, especially for bioavailability enhancement of poorly water-soluble drugs. Wet stirred media milling (WSMM) is the most widely used… read more here.
Keywords: stirred media; wet stirred; drug nanosuspensions; mechanistic modeling ... See more keywords
Mechanistic modeling of insecticide risks to breeding birds in North American agroecosystems
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0176998
Abstract: Insecticide usage in the United States is ubiquitous in urban, suburban, and rural environments. There is accumulating evidence that insecticides adversely affect non-target wildlife species, including birds, causing mortality, reproductive impairment, and indirect effects through… read more here.
Keywords: insecticide risks; risk; mechanistic modeling; risks breeding ... See more keywords
Mechanistic modeling as an explanatory tool for clinical treatment of chronic catatonia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1025417
Abstract: Mathematical modeling of neural systems is an effective means to integrate complex information about the brain into a numerical tool that can help explain observations. However, the use of neural models to inform clinical decisions… read more here.
Keywords: modeling explanatory; clinical treatment; catatonia; model ... See more keywords