Mechanistic perspective and functional activity of insulin in amylin aggregation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00481a
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DOI: 10.1039/c8sc00481a
Abstract: This work provides the first-ever complete atomic model of insulin–amylin aggregates, identifying the specific interactions that stabilize the insulin–amylin complex. read more here.
Keywords: mechanistic perspective; perspective functional; functional activity; insulin amylin ... See more keywords
Gone with the Wnt(less): a mechanistic perspective on the journey of Wnt.
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DOI: 10.1042/bst20220634
Abstract: Wnts are short-range signaling proteins, expressed in all metazoans from sponges to humans, critical for cell development and fate. There are 19 different Wnts in the human genome with varying expression levels and patterns, and… read more here.
Keywords: less mechanistic; perspective journey; gone wnt; wnt less ... See more keywords
Causal logics and mechanisms in policy design: How and why adopting a mechanistic perspective can improve policy design
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DOI: 10.1177/0952076719827068
Abstract: Policy design undertakes to develop effective policies and hence must understand whether and how effective policies can be formulated and implemented. However, very often policy design has failed to focus on the causal chain that… read more here.
Keywords: policy design; policy; mechanistic perspective; causal ... See more keywords