Mechanistic perspectives on differential mitochondrial-based neuroprotective effects of several carnitine forms in Alzheimer's disease in vitro model.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of toxicology"
DOI: 10.1007/s00204-021-03104-1
Abstract: Mitochondrial deregulation has emerged as one of the earliest pathological events in Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. Improvement of mitochondrial function in AD has been considered a relevant therapeutic approach. L-carnitine… read more here.
Keywords: mechanistic perspectives; alzheimer disease; mitochondrial function; perspectives differential ... See more keywords
Mechanistic perspectives on piperidine-catalyzed synthesis of 1,5-benzodiazepin-2-ones
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2020.110774
Abstract: Abstract This work introduced new members to the pharmaceutical family of 1,5-benzodiazepin-2-ones, 2a–e. These compounds were synthesized in moderate yields via the reaction of 1,2-bifunctional substrates (α-cyanocinnamates) with o-phenylenediamine in xylene. The conduction of the… read more here.
Keywords: mechanistic perspectives; catalyzed synthesis; benzodiazepin ones; perspectives piperidine ... See more keywords