Articles with "mechanistic reconstruction" as a keyword



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Mechanistic reconstruction of glycoprotein secretion through monitoring of intracellular N-glycan processing

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Published in 2019 at "Science Advances"

DOI: 10.1126/sciadv.aax8930

Abstract: Kinetic analysis of intracellular intermediates affords a mathematical model for N-glycoprotein processing and secretion. N-linked glycosylation plays a fundamental role in determining the thermodynamic stability of proteins and is involved in multiple key biological processes.… read more here.

Keywords: secretion; processing; mechanistic reconstruction; glycan processing ... See more keywords