Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26
Sign Up to like & getrecommendations! Published in 2018 at "Febs Letters"
DOI: 10.1002/1873-3468.13231
Abstract: N‐Methylation of lysyl residues is widely observed on histone proteins. Using isolated enzymes, we report mechanistic and structural studies on histone lysine demethylase (KDM)‐catalysed demethylation of Nε‐methylated lysine 26 on histone 1 isotype 4 (H1.4).… read more here.
Keywords: kdm catalysed; demethylation; structural studies; catalysed demethylation ... See more keywords
Mechanistic and Structural Analyses of Non-Heme Iron Enzyme TqaM for α-Tertiary Amino Acid Synthesis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c14662
Abstract: α-Tertiary amino acids (ATAAs) are versatile building blocks for the synthesis of biologically active compounds. Although synthetic and enzymatic approaches to ATAA synthesis have been developed, additional methods for ATAA production remain in high demand.… read more here.
Keywords: non heme; mechanistic structural; synthesis; amino ... See more keywords
Polyglutamic Acid as an Antiviral Agent: Mechanistic and Structural Insights
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics17101296
Abstract: Poly-γ-glutamic acid (γ-PGA), also known as polyglutamate, is a naturally derived polymer produced by Bacillus species that has demonstrated antiviral properties. Growing evidence from preclinical and clinical studies supports its therapeutic potential against various viral… read more here.
Keywords: mechanistic structural; agent mechanistic; antiviral agent; structural insights ... See more keywords