From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells
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DOI: 10.1093/toxsci/kfx062
Abstract: Several endothelin receptor antagonists (ERAs) have been developed for the treatment of pulmonary arterial hypertension (PAH). Some of them have been related to clinical cases of hepatocellular injury (sitaxentan [SIT]) and/or cholestasis (bosentan [BOS]). We… read more here.
Keywords: mechanisticinsights cytotoxic; heparg cells; cover mechanisticinsights; receptor antagonists ... See more keywords