Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2302837120
Abstract: Significance Contraction of skeletal muscle is triggered by regulatory structural changes in the thin filaments following calcium binding to troponin. Structural changes in the thick filaments control the availability of myosin motors for actin interaction… read more here.
Keywords: muscle; activation skeletal; mechano sensing; filament ... See more keywords
R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing
Sign Up to like & getrecommendations! Published in 2019 at "Tissue Barriers"
DOI: 10.1080/21688370.2019.1653748
Abstract: ABSTRACT The barrier function of epithelia and endothelia depends on tight junctions, which are formed by the polymerization of claudins on a scaffold of ZO proteins. Two differentially spliced isoforms of ZO-1 have been described,… read more here.
Keywords: mechano sensing; epithelial differentiation; r40 binds; binds domain ... See more keywords