Mechano-Sensitive Synthetic Ion Channels.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b09515
Abstract: Mechanical stress is a ubiquitous stimulus sensed by membrane proteins, but rarely by synthetic molecules. Inspired by mechano-sensitive ion channels found in cell membranes, tension-responsive transmembrane multiblock amphiphiles were developed. In membranes, a single-transmembrane amphiphile… read more here.
Keywords: ion channels; mechano sensitive; ion; sensitive synthetic ... See more keywords
A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005259
Abstract: Vascularisation is a key feature of cancer growth, invasion and metastasis. To better understand the governing biophysical processes and their relative importance, it is instructive to develop physiologically representative mathematical models with which to compare… read more here.
Keywords: silico model; multiscale silico; angiogenesis; mechano sensitive ... See more keywords
Does the Heart Want What It Wants? A Case for Self-Adapting, Mechano-Sensitive Therapies After Infarction
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.705100
Abstract: There is a critical need for interventions to control the development and remodeling of scar tissue after myocardial infarction. A significant hurdle to fibrosis-related therapy is presented by the complex spatial needs of the infarcted… read more here.
Keywords: adapting mechano; heart want; mechano sensitive; case ... See more keywords
Emergence of Mechano-Sensitive Contraction Autoregulation in Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2021 at "Life"
DOI: 10.3390/life11060503
Abstract: The heart has two intrinsic mechanisms to enhance contractile strength that compensate for increased mechanical load to help maintain cardiac output. When vascular resistance increases the ventricular chamber initially expands causing an immediate length-dependent increase… read more here.
Keywords: autoregulation; emergence mechano; autoregulation cardiomyocytes; mechano sensitive ... See more keywords