C-4 Regioselective Alkylation of Pyridines Driven by Mechanochemically Activated Magnesium Metal.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00684
Abstract: Mechanochemically activated magnesium(0) metal as a highly active mediator driving direct C-4-H alkylation of pyridines with alkyl halides has been developed. Excellent regioselectivity and substrate scope, including those containing reducible functionalities, free amines, and alcohols,… read more here.
Keywords: activated magnesium; magnesium metal; alkylation pyridines; mechanochemically activated ... See more keywords
Mechanochemically Activated Asymmetric Organocatalytic Domino Mannich Reaction-Fluorination
Sign Up to like & getrecommendations! Published in 2020 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.0c04260
Abstract: Mechanochemical activation effectively mediated asymmetric organocatalytic domino Mannich addition followed by diastereoselective fluorination. The Mannich reactions of pyrazolones and to a lesser ... read more here.
Keywords: fluorination; mechanochemically activated; organocatalytic domino; asymmetric organocatalytic ... See more keywords