Structure and mechanogating mechanism of the Piezo1 channel
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DOI: 10.1038/nature25743
Abstract: The mechanosensitive Piezo channels function as key eukaryotic mechanotransducers. However, their structures and mechanogating mechanisms remain unknown. Here we determine the three-bladed, propeller-like electron cryo-microscopy structure of mouse Piezo1 and functionally reveal its mechanotransduction components.… read more here.
Keywords: mechanogating mechanism; mechanism piezo1; structure mechanogating; structure ... See more keywords
Structure-guided examination of the mechanogating mechanism of PIEZO2
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1905985116
Abstract: Significance Aristotle’s five senses—sight, smell, taste, hearing, and touch—are crucial for the perception of and interaction with the environment. While the molecular machineries that detect visual, olfactory, gustatory, and auditory stimuli are well characterized, comparatively… read more here.
Keywords: mechanosensitivity; mechanogating mechanism; mechanism piezo2; piezo2 ... See more keywords