Molecular Tension Probes to Investigate the Mechanopharmacology of Single Cells: A Step toward Personalized Mechanomedicine
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800069
Abstract: Given that dysregulation of mechanics contributes to diseases ranging from cancer metastasis to lung disease, it is important to develop methods for screening the efficacy of drugs that target cellular forces. Here, nanoparticle-based tension sensors… read more here.
Keywords: probes investigate; mechano ec50; mechanopharmacology; molecular tension ... See more keywords
Mechanopharmacology of Rho-kinase antagonism in airway smooth muscle and potential new therapy for asthma.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104995
Abstract: The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the premise that physical agitation, such as pressure oscillation applied to an airway, is able to induce bronchodilation by reducing contractility and softening… read more here.
Keywords: mechanopharmacology; muscle; smooth muscle; rho kinase ... See more keywords