Polymodal Functionality of C. elegans OLL Neurons in Mechanosensation and Thermosensation
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DOI: 10.1007/s12264-021-00629-4
Abstract: Sensory modalities are important for survival but the molecular mechanisms remain challenging due to the polymodal functionality of sensory neurons. Here, we report the C. elegans outer labial lateral (OLL) sensilla sensory neurons respond to… read more here.
Keywords: neurons mechanosensation; polymodal functionality; oll neurons; mechanosensation ... See more keywords
Microtubule Acetylation Is Required for Mechanosensation in Drosophila.
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DOI: 10.1016/j.celrep.2018.09.075
Abstract: At the cellular level, α-tubulin acetylation alters the structure of microtubules to render them mechanically resistant to compressive forces. How this biochemical property of microtubule acetylation relates to mechanosensation remains unknown, although prior studies have shown… read more here.
Keywords: drosophila; microtubule; acetylation; acetylation required ... See more keywords
Cell disorientation by loss of SHH-dependent mechanosensation causes cyclopia
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DOI: 10.1126/sciadv.abn2330
Abstract: The physical causes of organ malformation remain largely unclear in most cases due to a lack of information on tissue/cell dynamics. Here, we address this issue by considering onset of cyclopia in sonic hedgehog (SHH)–inhibited… read more here.
Keywords: shh dependent; cell; shh; cell disorientation ... See more keywords
Ciliary mechanosensation - roles of polycystins and mastigonemes.
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DOI: 10.1242/jcs.260565
Abstract: Cilia are surface-exposed organelles that provide motility and sensory functions for cells, and it is widely believed that mechanosensation can be mediated through cilia. Polycystin-1 and -2 (PC-1 and PC-2, respectively) are transmembrane proteins that… read more here.
Keywords: mechanosensation roles; mechanosensation; roles polycystins; ciliary mechanosensation ... See more keywords
Gabapentin Disrupts Binding of Perlecan to the α2δ1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12121857
Abstract: Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering elements” (TEs) spanning the pericellular space of osteocytes and transmitting mechanical information into biochemical signals.… read more here.
Keywords: voltage sensitive; bone; mechanosensation; gbp ... See more keywords