Role of mechanosensitive ion channels in the sensation of pain
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02182-2
Abstract: Our ability to sense mechanical cues from our environment depend on the capacity of molecular sensor capable of converting mechanical energy into biochemical or electrical signals. This process, termed mechanotransduction, relies on the activity of… read more here.
Keywords: mechanosensitive ion; ion channels; channels sensation; role mechanosensitive ... See more keywords
Electricity auto-generating skin patch promotes wound healing process by activation of mechanosensitive ion channels.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120948
Abstract: Electricity constitutes a natural biophysical component that preserves tissue homeostasis and modulates many biological processes, including the repair of damaged tissues. Wound healing involves intricate cellular events, such as inflammation, angiogenesis, matrix synthesis, and epithelialization… read more here.
Keywords: wound healing; mechanosensitive ion; ion channels; electricity auto ... See more keywords
Magnetogenetics with Piezo1 Mechanosensitive Ion Channel for CRISPR Gene Editing.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c02314
Abstract: Regulation of genetic activity in single cells and tissues is pivotal to determine key cellular functions in current biomedicine, yet the conventional biochemical activators lack spatiotemporal precision due to the diffusion-mediated slow kinetics and nonselectivity.… read more here.
Keywords: crispr; ion channel; gene editing; mechanosensitive ion ... See more keywords
Freestanding lipid bilayer tensiometer for the study of mechanosensitive ion channels
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221541120
Abstract: Significance Stretch-activated ion channels respond to tension in cellular membranes, transducing mechanical stimuli into physiological responses, including the sense of touch and blood pressure regulation. However, the precise measurement of tensions required to activate mechanosensitive… read more here.
Keywords: freestanding lipid; mechanosensitive ion; tension; ion channels ... See more keywords
The Mechanosensitive Ion Channel PIEZO1 in Intestinal Epithelial Cells Mediates Inflammation through the NOD-Like Receptor 3 Pathway in Crohn's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izac152
Abstract: BACKGROUND Crohn's disease (CD) is an incurable chronic intestinal inflammatory disease with no recognized cause. It has been reported that the mechanosensitive ion channel PIEZO1 initiates proinflammatory responses. However, little is known about the role… read more here.
Keywords: calcium; ion channel; disease; crohn disease ... See more keywords
Interactions between the N- and C- termini of mechanosensitive ion channel AtMSL10 are consistent with a three-step mechanism for activation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of experimental botany"
DOI: 10.1093/jxb/eraa192
Abstract: Although a growing number of mechanosensitive ion channels are being identified in plant systems, the molecular mechanisms by which they function are still under investigation. Overexpression of the mechanosensitive ion channel MSL (MscS-Like)10 fused to… read more here.
Keywords: three step; mechanosensitive ion; ion; ion channel ... See more keywords
Unbiased proteomic and forward genetic screens reveal that mechanosensitive ion channel MSL10 functions at ER–plasma membrane contact sites in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.05.23.493056
Abstract: Mechanosensitive (MS) ion channels are an evolutionarily conserved way for cells to sense mechanical forces and transduce them into ionic signals. The channel properties of Arabidopsis thaliana MscS-Like (MSL)10 have been well studied, but how… read more here.
Keywords: membrane contact; mechanosensitive ion; forward genetic; msl10 ... See more keywords
The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental physiology"
DOI: 10.1113/ep090776
Abstract: NEW FINDINGS What is the central question of this study? Proprioception is initiated by mechanosensitive neurons. However, the identities of the molecular players that mediate proprioceptive sensing are largely unknown. Here, we aimed to identify… read more here.
Keywords: ion channel; proprioceptive sensing; asic2; alignment ... See more keywords
The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abj5557
Abstract: How mechanical stress affects physical performance via tendons is not fully understood. Piezo1 is a mechanosensitive ion channel, and E756del PIEZO1 was recently found as a gain-of-function variant that is common in individuals of African… read more here.
Keywords: function; physical performance; performance; mechanosensitive ion ... See more keywords
Membrane stretch due to hypoosmolality leads to the development of various pulmonary and cardiovascular diseases
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733959
Abstract: High blood pressures over a long period of time can lead to the development of diseases such as congestive heart failure(CHF). Congestive heart failure also commonly leads to the development of conditions such as hyponatremia,… read more here.
Keywords: leads development; hypoosmotic conditions; development; microscopy ... See more keywords
The role of mechanosensitive ion channels in the gastrointestinal tract
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.904203
Abstract: Mechanosensation is essential for normal gastrointestinal (GI) function, and abnormalities in mechanosensation are associated with GI disorders. There are several mechanosensitive ion channels in the GI tract, namely transient receptor potential (TRP) channels, Piezo channels,… read more here.
Keywords: role mechanosensitive; mechanosensitive ion; ion; ion channels ... See more keywords