A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01712-z
Abstract: Piezo proteins are bona fide mammalian mechanotransduction channels for various cell types including endothelial cells. The mouse Piezo1 of 2547 residues forms a three-bladed, propeller-like homo-trimer comprising a central pore-module and three propeller-structures that might… read more here.
Keywords: piezo channels; mechanosensitive piezo; piezo; mechanotransduction ... See more keywords
Voltage gating of mechanosensitive PIEZO channels
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03502-7
Abstract: Mechanosensitive PIEZO ion channels are evolutionarily conserved proteins whose presence is critical for normal physiology in multicellular organisms. Here we show that, in addition to mechanical stimuli, PIEZO channels are also powerfully modulated by voltage… read more here.
Keywords: voltage; piezo channels; mechanosensitive piezo; piezo ... See more keywords