c‐Src kinase contributes on endothelial cells mechanotransduction in a heat shock protein 70‐dependent turnover manner
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27787
Abstract: Shear stress changes are associated with a repertory of signaling cascade modulating vascular phenotype. As shear stress‐related tensional forces might be associated with pathophysiological susceptibility, a more comprehensive molecular map needs to be addressed. Thus,… read more here.
Keywords: protein; turnover; shear stress; mechanotransduction ... See more keywords
Mechanotransduction in neuronal cell development and functioning
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Reviews"
DOI: 10.1007/s12551-019-00587-2
Abstract: Although many details remain still elusive, it became increasingly evident in recent years that mechanosensing of microenvironmental biophysical cues and subsequent mechanotransduction are strongly involved in the regulation of neuronal cell development and functioning. This… read more here.
Keywords: cell development; neuronal cell; mechanotransduction; development functioning ... See more keywords
Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical Reviews"
DOI: 10.1007/s12551-021-00839-0
Abstract: Shear stress is known to affect many processes in (patho-) physiology through a complex, multi-molecular mechanism, termed mechanotransduction. The sheer complexity of the process has raised questions how mechanotransduction is regulated. Here, we comprehensively evaluate… read more here.
Keywords: pathways regulated; mirna clusters; mechanotransduction; regulated mechanosensitive ... See more keywords
Cell stretchers and the LINC complex in mechanotransduction.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108829
Abstract: How cells respond to mechanical forces from the surrounding environment is critical for cell survival and function. The LINC complex is a central component in the mechanotransduction pathway that transmits mechanical information from the cell… read more here.
Keywords: stretchers linc; linc complex; respond mechanical; mechanotransduction ... See more keywords
The role of sphingosine-1-phosphate signaling pathway in cementocyte mechanotransduction.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.003
Abstract: Iatrogenic external root resorption can become a serious pathological condition with clinical tooth movement. Little is known regarding how cementum responds to mechanical loading in contrast to bone, especially under compressive stress. In the field… read more here.
Keywords: sphingosine phosphate; compressive stress; s1p signaling; mechanotransduction ... See more keywords
Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2021.08.026
Abstract: Abstract Cell behaviors and functions show distinct contrast in different mechanical microenvironment. Numerous materials with varied rigidity have been developed to mimic the interactions between cells and their surroundings. However, the conventional static materials cannot… read more here.
Keywords: flexible materials; overcomes hard; mechanotransduction; hard flexible ... See more keywords
Adaptable boronate ester hydrogels with tunable viscoelastic spectra to probe timescale dependent mechanotransduction.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119430
Abstract: Cells are capable of sensing the differences in elastic and viscous properties (i.e., the 'viscoelasticity') of their tissue microenvironment and responding accordingly by changing their transcriptional activity and modifying their behaviors. When designing viscoelastic materials… read more here.
Keywords: viscoelastic spectra; timescale dependent; mechanotransduction; tunable viscoelastic ... See more keywords
Bone marrow mechanotransduction in porcine explants alters kinase activation and enhances trabecular bone formation in the absence of osteocyte signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Bone"
DOI: 10.1016/j.bone.2017.11.007
Abstract: Bone is a dynamic tissue that can adapt its architecture in response to mechanical signals under the control of osteocytes, which sense mechanical deformation of the mineralized bone. However, cells in the marrow are also… read more here.
Keywords: bone formation; mechanotransduction; bone; marrow ... See more keywords
Rapping about Mechanotransduction.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.09.007
Abstract: Mechanical cues can regulate cell proliferation and differentiation through the Hippo-YAP signaling network. Reporting in Nature, Meng et al. (2018) show that the Ras-related GTPase RAP2 connects extracellular matrix stiffness to Hippo pathway regulation, adding to… read more here.
Keywords: rapping mechanotransduction; mechanotransduction;
Torsional and translational vibrations of a eukaryotic nucleus, and the prospect of vibrational mechanotransduction and therapy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of The Mechanics and Physics of Solids"
DOI: 10.1016/j.jmps.2021.104572
Abstract: Abstract Certain eukaryotic cells are believed to sense and respond to vibrational stimuli that are too small even to be transduced by mechanosensitive ion channels. One possible mechanism of signal amplification and transduction is torsional… read more here.
Keywords: translational vibrations; eukaryotic nucleus; torsional translational; nucleus prospect ... See more keywords
Volume adaptation controls stem cell mechanotransduction.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b19770
Abstract: Recent studies have found discordant mechanosensitive outcomes when comparing 2D and 3D, highlighting the need for tools to study mechanotransduction in 3D across a wide spectrum of stiffness. A gelatin methacryloyl (GelMA) hydrogel with a… read more here.
Keywords: stem cell; stiffness; volume; mechanotransduction ... See more keywords