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   Articles with "mecom" as a keyword



Molecular approaches identify a cryptic MECOM rearrangement in a child with a rapidly progressive myeloid neoplasm.

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recommendations! Published in 2018 at "Cancer genetics"

DOI: 10.1016/j.cancergen.2017.12.002

Abstract: Myeloid neoplasms are a heterogeneous group of hematologic disorders with divergent patterns of cell differentiation and proliferation, as well as divergent clinical courses. Rare recurrent genetic abnormalities related to this group of cancers are associated… read more here.

Keywords: myeloid neoplasms; myeloid neoplasm; molecular approaches; mecom ... See more keywords

Modelling and drug targeting of a myeloid neoplasm with atypical 3q26/MECOM rearrangement using patient‐specific iPSCs

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recommendations! Published in 2024 at "British Journal of Haematology"

DOI: 10.1111/bjh.19720

Abstract: Structural variations involving enhancer hijacking induce aberrant oncogene expression and cause tumorigenesis. A rare translocation, t(3;8)(q26.2;q24), is associated with MECOM and MYC rearrangement, causing myeloid neoplasms with a dismal prognosis. The most recent World Health… read more here.

Keywords: drug; mecom; mecom rearrangement; enhancer hijacking ... See more keywords

MECOM fusion partner and bone marrow blast percentage influence outcomes of patients with MECOM rearranged acute myeloid leukaemia.

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recommendations! Published in 2025 at "British journal of haematology"

DOI: 10.1111/bjh.70171

Abstract: MECOM rearrangements (MECOM‐r) are acute myeloid leukaemia (AML)‐defining, regardless of blast percentage or MECOM fusion partner. We sought to investigate if blast percentage or MECOM‐r partner was associated with overall survival (OS). We included 152… read more here.

Keywords: myeloid leukaemia; acute myeloid; partner; mecom ... See more keywords

Abstract 1324: MECOM a novel player in AR-driven treatment resistant castration-resistant prostate cancer

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-1324

Abstract: The androgen receptor (AR) remains a pivotal target in castration-resistant prostate cancer (CRPC), as its continued activity presents a therapeutic vulnerability. Reprogramming of the AR cistrome, shifting from a canonical (typical or standard) to a… read more here.

Keywords: cancer; resistant prostate; prostate cancer; castration resistant ... See more keywords

Targeted Protein Degradation Reveals a Repressive Role of Mecom at the CEBPA Locus to Prevent Differentiation in High-Risk Acute Myeloid Leukemia

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-199697

Abstract: Increasing evidence suggests that acquiring hematopoietic stem cell (HSC) gene expression programs in acute myeloid leukemia (AML) confers a particularly poor prognosis and increases the risk of relapse. However, the precise basis by which high-risk… read more here.

Keywords: differentiation; high risk; cell; expression ... See more keywords

Clonal Hematopoiesis Can Precede AML with Defining Cytogenetic Abnormalities - the Frequencies Vary Considerably

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-204966

Abstract: Background: The 5th edition of the WHO Classification of Haematolymphoid Tumours (WHO 2022) highlights the importance of cytogenetic and molecular abnormalities in AML as disease-defining criteria. Mutations in genes frequently mutated in clonal hematopoiesis (CH)… read more here.

Keywords: aml defining; group; clonal hematopoiesis; pml rara ... See more keywords

High protein expression of MDS1 and EVI1 complex locus (MECOM) is prognostically adverse and independent of chromosome 3 rearrangements in acute myelogenous leukemia

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-5258

Abstract: INTRODUCTION: The MDS1 and EVI1 Complex Locus (MECOM), located at chromosome 3q26.2 is rearranged (MECOM-R) in ~1.5% of Acute Myelogenous Leukemia (AML) cases, and confers an adverse prognosis. MECOM-R causes overexpression of Ecotropic viral integration… read more here.

Keywords: evi high; ch3; protein; evi1 ... See more keywords

Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia.

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood.2019003701

Abstract: Acute myeloid leukemia (AML) with inv(3)/t(3;3)(q21q26) is a distinct WHO recognized entity, characterized by its aggressive course and poor prognosis. In this subtype of AML, the translocation of a GATA2 enhancer (3q21) to MECOM (3q26)… read more here.

Keywords: atypical 3q26; mecom; mecom rearrangements; acute myeloid ... See more keywords

CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias.

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood.2025028954

Abstract: Acute myeloid leukemias (AMLs) have an overall poor prognosis with many high-risk cases co-opting stem-cell gene regulatory programs, yet the mechanisms through which this occurs remain poorly understood. Increased expression of the stem-cell transcription factor,… read more here.

Keywords: leukemias; stem cell; repression mecom; cebpa repression ... See more keywords

MECOM: a bioinformatics and experimentally identified marker for the diagnosis and prognosis of lung adenocarcinoma.

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recommendations! Published in 2024 at "Biomarkers in medicine"

DOI: 10.2217/bmm-2023-0600

Abstract: Objective: We aimed to explore the clinical value of MDS1 and EVI1 complex locus (MECOM) in lung adenocarcinoma (LUAD). Methods: Bioinformatics and experimental validation confirmed MECOM expression levels in LUAD. The value of MECOM was… read more here.

Keywords: lung adenocarcinoma; mecom; bioinformatics experimentally; mecom bioinformatics ... See more keywords

3q26.2/MECOM Rearrangements by Pericentric Inv(3): Diagnostic Challenges and Clinicopathologic Features

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recommendations! Published in 2023 at "Cancers"

DOI: 10.3390/cancers15020458

Abstract: Simple Summary In this study, 17 acute myeloid leukemia (AML) patients were identified to pose a pericentric inv(3) aberration with breakpoints at 3p23 (n = 11), 3p25 (n = 3), 3p21 (n = 2) and… read more here.

Keywords: mecom; pericentric inv; 3q26 mecom; fish analysis ... See more keywords