Molecular approaches identify a cryptic MECOM rearrangement in a child with a rapidly progressive myeloid neoplasm.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2017.12.002
Abstract: Myeloid neoplasms are a heterogeneous group of hematologic disorders with divergent patterns of cell differentiation and proliferation, as well as divergent clinical courses. Rare recurrent genetic abnormalities related to this group of cancers are associated… read more here.
Keywords: myeloid neoplasms; myeloid neoplasm; molecular approaches; mecom ... See more keywords
Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia.
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DOI: 10.1182/blood.2019003701
Abstract: Acute myeloid leukemia (AML) with inv(3)/t(3;3)(q21q26) is a distinct WHO recognized entity, characterized by its aggressive course and poor prognosis. In this subtype of AML, the translocation of a GATA2 enhancer (3q21) to MECOM (3q26)… read more here.
Keywords: atypical 3q26; mecom; mecom rearrangements; acute myeloid ... See more keywords
3q26.2/MECOM Rearrangements by Pericentric Inv(3): Diagnostic Challenges and Clinicopathologic Features
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DOI: 10.3390/cancers15020458
Abstract: Simple Summary In this study, 17 acute myeloid leukemia (AML) patients were identified to pose a pericentric inv(3) aberration with breakpoints at 3p23 (n = 11), 3p25 (n = 3), 3p21 (n = 2) and… read more here.
Keywords: mecom; pericentric inv; 3q26 mecom; fish analysis ... See more keywords