Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia.
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DOI: 10.1182/blood.2019003701
Abstract: Acute myeloid leukemia (AML) with inv(3)/t(3;3)(q21q26) is a distinct WHO recognized entity, characterized by its aggressive course and poor prognosis. In this subtype of AML, the translocation of a GATA2 enhancer (3q21) to MECOM (3q26)… read more here.
Keywords: atypical 3q26; mecom; mecom rearrangements; acute myeloid ... See more keywords
A Relapsed AML Case Featuring MYC and MECOM Rearrangements
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DOI: 10.3390/diagnostics15182410
Abstract: Background/Objectives: Relapsed acute myeloid leukemia (AML) is often characterized by clonal evolution and acquired genomic abnormalities, which can inform prognosis and direct therapeutic decisions. The emergence of high-risk chromosomal rearrangements during relapse is of particular… read more here.
Keywords: myc mecom; aml case; case featuring; case ... See more keywords