Differential Regulation of MeCP2 Phosphorylation by Laminin in Oligodendrocytes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0939-4
Abstract: Oligodendrocytes (OLGs) are the myelinating cells of the central nervous system (CNS), and its proper differentiation is crucial for normal functioning of neurons. Methyl-CpG-binding protein 2 (MeCP2) is a multifunctional methylated DNA binding protein; mutation… read more here.
Keywords: mecp2; differential regulation; laminin; mecp2 phosphorylation ... See more keywords
Emerging physiological and pathological roles of MeCP2 in non-neurological systems.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108768
Abstract: Numerous neurological and non-neurological disorders are associated with dysfunction of epigenetic modulators, and methyl CpG binding protein 2 (MeCP2) is one of such proteins. Initially identified as a transcriptional repressor, MeCP2 specifically binds to methylated… read more here.
Keywords: emerging physiological; non neurological; physiological pathological; pathological roles ... See more keywords
Methyl-CpG binding protein 2 is associated with the prognosis and mortality of elderly patients with hip fractures
Sign Up to like & getrecommendations! Published in 2022 at "Clinics"
DOI: 10.1016/j.clinsp.2022.100034
Abstract: Highlights • MECP2 was downregulated in elderly patients with hip fracture.• MECP2 was correlated with inflammatory factors in hip fractures.• Lower MECP2 predicted poor clinical outcomes of hip fractures.• Lower MECP2 predicted higher mortality and… read more here.
Keywords: patients hip; mecp2; elderly patients; mortality ... See more keywords
M39 THE ASSOCIATION OF METHYLATION OF THE PROMOTER AND ANTIDEPRESSANTS IN TRANSCRIPTIONAL REGULATION OF THE BRAIN-DERIVED NEUROTROPHIC FACTOR EXON IV
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.346
Abstract: Background Brain-Derived Neurotrophic Factor (BDNF) is important for the survival of existing neurons and promotion of the growth and differentiation of new neurons and synapses. BDNF protein expression has been associated with various psychiatric disorders… read more here.
Keywords: brain derived; methylation; derived neurotrophic; mecp2 ... See more keywords
First description of an unusual novel double mutation in MECP2 co-occurring with the m.827A>G mutation in the MT-RNR1 gene associated with angelman-like syndrome
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Developmental Neuroscience"
DOI: 10.1016/j.ijdevneu.2019.10.002
Abstract: Mutations in Methyl‐CpG‐Binding protein 2 (MECP2), located on Xq28 and encoding a methyl CpG binding protein, are commonly related to Rett syndrome. However, MECP2 mutations have already been reported in patients with neurodevelopmental abnormalities such… read more here.
Keywords: novel double; mecp2; double mutation; unusual novel ... See more keywords
Brain protein changes in Mecp2 mouse mutant models: Effects on disease progression of Mecp2 brain specific gene reactivation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.103537
Abstract: Rett syndrome (RTT) is a leading cause of severe intellectual disability in females, caused by de novo loss-of function mutations in the X-linked methyl-CpG binding protein 2 (MECP2). To better investigate RTT disease progression/pathogenesis animal… read more here.
Keywords: protein; mecp2 mouse; mecp2; disease progression ... See more keywords
Neuronal non-CG methylation is an essential target for MeCP2 function
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.01.011
Abstract: Summary DNA methylation is implicated in neuronal biology via the protein MeCP2, the mutation of which causes Rett syndrome. MeCP2 recruits the NCOR1/2 co-repressor complexes to methylated cytosine in the CG dinucleotide, but also to… read more here.
Keywords: methylation; rett syndrome; mecp2; non methylation ... See more keywords
Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2018.02.010
Abstract: HIGHLIGHTSMeCP2 in the adult hippocampus is required for long‐term memory formation.MeCP2 maintains the chromatin features of mature CA1 neurons.MeCP2 preserves the genomic responsiveness to hippocampus‐dependent learning. ABSTRACT MeCP2 is required both during postnatal neurodevelopment and… read more here.
Keywords: adult; hippocampus; long term; mecp2 ... See more keywords
Advances in understanding of Rett syndrome and MECP2 duplication syndrome: prospects for future therapies
Sign Up to like & getrecommendations! Published in 2020 at "The Lancet Neurology"
DOI: 10.1016/s1474-4422(20)30217-9
Abstract: The X-linked gene encoding MECP2 is involved in two severe and complex neurodevelopmental disorders. Loss of function of the MeCP2 protein underlies Rett syndrome, whereas duplications of the MECP2 locus cause MECP2 duplication syndrome. Research… read more here.
Keywords: duplication syndrome; mecp2 duplication; advances understanding; mecp2 ... See more keywords
Dose-Dependent Nuclear Delivery and Transcriptional Repression with a Cell-Penetrant MeCP2
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01226
Abstract: Methyl-CpG-binding-protein 2 (MeCP2) is a nuclear protein expressed in all cell types, especially neurons1. Mutations in the MECP2 gene cause Rett syndrome (RTT), an incurable neurological disorder that disproportionately affects young girls2. Strategies to restore… read more here.
Keywords: cell; cell penetrant; nuclear delivery; mecp2 ... See more keywords
MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-018-0257-6
Abstract: Duplication of MECP2 (Methyl-CpG-binding protein 2) causes severe mental illness called MECP2 duplication syndrome (MDS), yet the underlying mechanism remains elusive. Here we show, in Tg(MECP2) transgenic mouse brain or cultured neural progenitor cells (NPCs),… read more here.
Keywords: npc differentiation; mecp2; expression; mir 197 ... See more keywords