Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.04.010
Abstract: Rett syndrome (RTT) is the second leading cause of mental impairment in girls and is currently untreatable. RTT is caused, in more than 95% of cases, by loss-of-function mutations in the methyl CpG-binding protein 2… read more here.
Keywords: mecp2 knockout; rett syndrome; inhibition; gsk3b ... See more keywords
Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201910889
Abstract: Mutations in the X‐linked MECP2 gene are responsible for Rett syndrome (RTT), a severe neurological disorder for which there is no treatment. Several studies have linked the loss of MeCP2 function to alterations of brain‐derived… read more here.
Keywords: phenotype mecp2; mecp2 knockout; mecp2; mice ... See more keywords