Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome
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DOI: 10.1007/s12035-018-1046-4
Abstract: Expression of MeCP2 must be carefully regulated as a reduction or increase results in serious neurological disorders. We are studying transgenic mice in which the MeCP2 gene is expressed at about three times higher than the… read more here.
Keywords: mecp2 triplication; mecp2 mice; triplication syndrome; mice ... See more keywords
Effects of early‐life exposure to THIP on brainstem neuronal excitability in the Mecp2‐null mouse model of Rett syndrome before and after drug withdrawal
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DOI: 10.14814/phy2.13110
Abstract: Rett syndrome (RTT) is mostly caused by mutations of the X‐linked MECP2 gene. Although the causal neuronal mechanisms are still unclear, accumulating experimental evidence obtained from Mecp2−/Y mice suggests that imbalanced excitation/inhibition in central neurons… read more here.
Keywords: thip; mecp2; early life; mecp2 mice ... See more keywords