Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome–like phenotypes
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DOI: 10.1172/jci90967
Abstract: Mutations in the X-linked gene encoding methyl-CpG–binding protein 2 (MeCP2) cause Rett syndrome (RTT), a neurological disorder affecting cognitive development, respiration, and motor function. Genetic restoration of MeCP2 expression reverses RTT-like phenotypes in mice, highlighting… read more here.
Keywords: like phenotypes; mecp2 t158m; rett syndrome; mecp2 ... See more keywords