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   Articles with "med1" as a keyword



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MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia

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recommendations! Published in 2022 at "Neurobiology of Disease"

DOI: 10.1016/j.nbd.2022.105611

Abstract: Central post-stroke pain (CPSP) and associated depression remain poorly understood and pharmacological treatments are unsatisfactory. Recently, microglia activation was suggested to be involved in CPSP pathophysiology. The goal of this study was to investigate the… read more here.

Keywords: bdnf; hemorrhage induced; med1; depression ... See more keywords
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MED1 Deficiency in Macrophages Accelerates Intimal Hyperplasia via ROS Generation and Inflammation

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recommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2021/3010577

Abstract: Mediator complex subunit 1 (MED1) is a component of the mediator complex and functions as a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Previously, we showed that MED1 in… read more here.

Keywords: med1 mac; hyperplasia; med1; med1 deficiency ... See more keywords
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HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1.

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recommendations! Published in 2018 at "Cancer research"

DOI: 10.1158/0008-5472.can-17-1533

Abstract: Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contributions to breast tumorigenesis, based on coamplification of MED1 and HER2… read more here.

Keywords: tumorigenesis; her2 driven; med1; breast tumorigenesis ... See more keywords
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MED1 Regulates BMP/TGF-β in Endothelium: Implication for Pulmonary Hypertension

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recommendations! Published in 2022 at "Circulation Research"

DOI: 10.1161/circresaha.122.321532

Abstract: Background: Dysregulated BMP (bone morphogenetic protein) or TGF-β (transforming growth factor beta) signaling pathways are imperative in idiopathic and familial pulmonary arterial hypertension (PAH) as well as experimental pulmonary hypertension (PH) in rodent models. MED1… read more here.

Keywords: bmp tgf; erg tgfbr2; pulmonary hypertension; endothelium ... See more keywords