CYP24A1 expression analysis in uterine leiomyoma regarding MED12 mutation profile
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DOI: 10.1007/s00404-020-05825-7
Abstract: Uterine leiomyoma (ULM) is the most common gynecological tumor. Recent studies have revealed the role of hypovitaminosis D as a major risk factor in the disease development. CYP24A, a mitochondrial enzyme that catalyzes the degradation… read more here.
Keywords: mutation profile; med12 mutation; expression; uterine leiomyoma ... See more keywords
Frequency of MED12 Mutation in Relation to Tumor and Patient’s Clinical Characteristics: a Meta-analysis
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DOI: 10.1007/s43032-021-00473-x
Abstract: Mediator complex subunit 12 (MED12) is the most frequently mutated gene in uterine leiomyomas (ULs)—with a frequency of up to 85%—suggesting that it plays key roles in the pathogenesis of ULs. However, there is no… read more here.
Keywords: analysis; med12 mutation; frequency med12; meta analysis ... See more keywords
Effects of female hormone withdrawal and ulipristal acetate on MED12 mutation positive and negative uterine leiomyomas using a xenograft model
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DOI: 10.1038/s41598-025-23721-5
Abstract: The effects of therapeutic drugs that inhibit female hormone functions on uterine leiomyomas (ULMs) vary among individuals. ULMs are classified into two subtypes with different histological compositions: MED12 mutation-positive and -negative ULMs. The present study… read more here.
Keywords: xenograft; withdrawal; uterine leiomyomas; med12 mutation ... See more keywords
Abstract 424: RTK inhibitor resistance in NSCLC harboring MED12 mutation is overcome by only blocking MEK signaling, not AKT due to mutated MED12-induced YAP-PTEN dysregulation
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DOI: 10.1158/1538-7445.am2023-424
Abstract: The advent of receptor tyrosine kinase inhibitors (RTKi) are important contributions to treat NSCLC patients harboring genetic aberration effectively. Nevertheless, the emergence of acquired or intrinsic RTKi resistance by other RTK activation bypass finally limits… read more here.
Keywords: rtk; med12 mutation; harboring med12; resistance ... See more keywords
The Effect of Race/Ethnicity and MED12 Mutation on the Expression of Long Non-Coding RNAs in Uterine Leiomyoma and Myometrium
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DOI: 10.3390/ijms25021307
Abstract: The objective of this study was to elucidate the expression of long non-coding RNA (lncRNA) in leiomyomas (Lyo) and paired myometrium (Myo) and explore the impact of race and MED12 mutation. Fold change analysis (Lyo/paired… read more here.
Keywords: med12; expression long; med12 mutation; race ... See more keywords