CYP24A1 expression analysis in uterine leiomyoma regarding MED12 mutation profile
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DOI: 10.1007/s00404-020-05825-7
Abstract: Uterine leiomyoma (ULM) is the most common gynecological tumor. Recent studies have revealed the role of hypovitaminosis D as a major risk factor in the disease development. CYP24A, a mitochondrial enzyme that catalyzes the degradation… read more here.
Keywords: mutation profile; med12 mutation; expression; uterine leiomyoma ... See more keywords
Frequency of MED12 Mutation in Relation to Tumor and Patient’s Clinical Characteristics: a Meta-analysis
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DOI: 10.1007/s43032-021-00473-x
Abstract: Mediator complex subunit 12 (MED12) is the most frequently mutated gene in uterine leiomyomas (ULs)—with a frequency of up to 85%—suggesting that it plays key roles in the pathogenesis of ULs. However, there is no… read more here.
Keywords: analysis; med12 mutation; frequency med12; meta analysis ... See more keywords
Abstract 424: RTK inhibitor resistance in NSCLC harboring MED12 mutation is overcome by only blocking MEK signaling, not AKT due to mutated MED12-induced YAP-PTEN dysregulation
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DOI: 10.1158/1538-7445.am2023-424
Abstract: The advent of receptor tyrosine kinase inhibitors (RTKi) are important contributions to treat NSCLC patients harboring genetic aberration effectively. Nevertheless, the emergence of acquired or intrinsic RTKi resistance by other RTK activation bypass finally limits… read more here.
Keywords: rtk; med12 mutation; harboring med12; resistance ... See more keywords