The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc)
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101227
Abstract: Objective Liver glycogen levels are dynamic and highly regulated by nutrient availability as the levels decrease during fasting and are restored during the feeding cycle. However, feeding in the presence of fructose in water suppresses… read more here.
Keywords: glycogen; med13; liver; expression ... See more keywords
Regulation of cardiac transcription by thyroid hormone and Med13.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.01.007
Abstract: Thyroid hormone (TH) is a key regulator of transcriptional homeostasis in the heart. While hypothyroidism is known to result in adverse cardiac effects, the molecular mechanisms that modulate TH signaling are not completely understood. Mediator… read more here.
Keywords: transcription; response; med13; ptu ... See more keywords
Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse†, ‡
Sign Up to like & getrecommendations! Published in 2018 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioy004
Abstract: Abstract Understanding factors that regulate zygotic genome activation (ZGA) is critical for determining how cells are reprogrammed to become totipotent or pluripotent. There is limited information regarding how this process occurs physiologically in early mammalian… read more here.
Keywords: genome activation; zygotic genome; med13; mediator complex ... See more keywords
Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1289
Abstract: Abstract Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, by using genome-wide CRISPR–Cas9… read more here.
Keywords: med13; cyclin; resistance; mediator complex ... See more keywords
Snf1 cooperates with the CWI MAPK pathway to mediate the degradation of Med13 following oxidative stress
Sign Up to like & getrecommendations! Published in 2018 at "Microbial Cell"
DOI: 10.15698/mic2018.08.641
Abstract: Eukaryotic cells, when faced with unfavorable environmental conditions, mount either pro-survival or pro-death programs. The conserved cyclin C-Cdk8 kinase plays a key role in this decision. Both are members of the Cdk8 kinase module that,… read more here.
Keywords: degradation; cwi mapk; med13; stress ... See more keywords
MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.2139/ssrn.4083382
Abstract: α-Synuclein (α-syn) is important in synucleinopathies such as Parkinson's disease (PD). While genome-wide association studies (GWASs) of synucleinopathies have identified many risk loci, the underlying genes have not been shown for most loci. Using Drosophila,… read more here.
Keywords: modifiers synuclein; med13; med13 glycolysis; neurodegeneration ... See more keywords