MED15, transforming growth factor beta 1 (TGF-β1), FcγRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma
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DOI: 10.1038/s41598-020-65145-3
Abstract: Owing to the high incidence and mortality of oral squamous cell carcinoma (OSCC), knowledge of its diagnostic and prognostic factors is of significant value. The biomarkers ‘CD16, CD57, transforming growth factor beta 1 (TGF-β1), and… read more here.
Keywords: cd57; med15; oral squamous; squamous cell ... See more keywords
Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus
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DOI: 10.1098/rsob.240110
Abstract: The members of the evolutionary conserved actin-binding Ezrin, Radixin and Moesin (ERM) protein family are involved in numerous key cellular processes in the cytoplasm. In the last decades, ERM proteins, like actin and other cytoskeletal… read more here.
Keywords: moesin; binding; med15; heat shock ... See more keywords
Abstract 6167: Defining the role of transcriptional coregulator MED15 in immune adaptation in cancer
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DOI: 10.1158/1538-7445.am2025-6167
Abstract: The immune system is widely recognized as an important regulator of cancer progression and metastasis, where immune cells can actively promote or inhibit tumor growth. Initially, immune cells act to eradicate cells with emerging cancerous… read more here.
Keywords: transcriptional coregulator; cancer; med15; role ... See more keywords
MED15::TFE3 Renal Cell Carcinomas: Report of Two New Cases and Review of the Literature Confirming Nearly Universal Multilocular Cystic Morphology
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DOI: 10.1177/10668969221143455
Abstract: We report two novel cases of Xp11 translocation renal cell carcinomas with the MED15::TFE3 gene fusion in adult females aged 40 and 74 years. Both cases were extensively cystic and contained only minimal clear cells… read more here.
Keywords: renal cell; report two; med15 tfe3; cell carcinomas ... See more keywords
Formation of nuclear condensates by the Mediator complex subunit Med15 in mammalian cells
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DOI: 10.1186/s12915-021-01178-y
Abstract: Background The Mediator complex is an evolutionarily conserved multi-subunit protein complex that plays major roles in transcriptional activation and is essential for cell growth, proliferation, and differentiation. Recent studies revealed that some Mediator subunits formed… read more here.
Keywords: med15; nuclear condensates; complex subunit; subunit med15 ... See more keywords
MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling
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DOI: 10.18632/oncotarget.13860
Abstract: Androgen deprivation therapy (ADT) is the main therapeutic option for advanced prostate cancer (PCa). After initial regression, most tumors develop into castration-resistant PCa (CRPC). Previously, we found the Mediator complex subunit MED15 to be overexpressed… read more here.
Keywords: androgen deprivation; pi3k mtor; med15;
Mediator Subunit Med15 Regulates Cell Morphology and Mating in Candida lusitaniae
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DOI: 10.3390/jof9030333
Abstract: Candida lusitaniae is an emerging opportunistic pathogenic yeast capable of shifting from yeast to pseudohyphae form, and it is one of the few Candida species with the ability to reproduce sexually. In this study, we… read more here.
Keywords: mediator subunit; candida lusitaniae; med15; cell separation ... See more keywords