A multiprotein regulatory module, MED16–MBR1&2, controls MED25 homeostasis during jasmonate signaling
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DOI: 10.1038/s41467-025-56041-3
Abstract: Mediator25 (MED25) has been ascribed as a signal-processing and -integrating center that controls jasmonate (JA)-induced and MYC2-dependent transcriptional output. A better understanding of the regulation of MED25 stability will undoubtedly advance our knowledge of the… read more here.
Keywords: multiprotein regulatory; gene expression; responsive gene; med16 ... See more keywords
MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer
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DOI: 10.3390/life12101461
Abstract: Recent studies have shown that the mediator complex (MED) plays a vital role in tumorigenesis and development, but the role of MED16 (mediator complex subunit 16) in breast cancer (BC) is not clear. Increasing evidence… read more here.
Keywords: mtor signalling; sensitivity; med16; tamoxifen ... See more keywords