PCH-2TRIP13 regulates spindle checkpoint strength.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e20-05-0310
Abstract: Spindle checkpoint strength is dictated by the number of unattached kinetochores, cell volume and cell fate. We show that the conserved AAA-ATPase, PCH-2/TRIP13, which remodels the checkpoint effector Mad2 from an active conformation to an… read more here.
Keywords: media see; spindle checkpoint; see text; text media ... See more keywords
Quantification of Microtubule Stutters: Dynamic Instability Behaviors that are Strongly Associated with Catastrophe.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e20-06-0348
Abstract: Microtubules (MTs) are cytoskeletal fibers that undergo dynamic instability (DI), a remarkable process involving phases of growth and shortening separated by stochastic transitions called catastrophe and rescue. Dissecting dynamic instability mechanism(s) requires first characterizing and… read more here.
Keywords: instability; growth; media see; catastrophe ... See more keywords
Quantitative Biophysical Metrics for Rapid Evaluation of Ovarian Cancer Metastatic Potential.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e21-08-0419
Abstract: Ovarian cancer is routinely diagnosed long after the disease has metastasized through the fibrous sub-mesothelium. Despite extensive research in the field linking ovarian cancer progression to increasingly poor prognosis, there are currently no validated cellular… read more here.
Keywords: ovarian cancer; metastatic potential; media see; see text ... See more keywords
WAVE facilitates polarized E-Cadherin transport.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-08-0322
Abstract: Cadherin dynamics drive morphogenesis, while defects in Cadherin polarity contribute to diseases, including cancers. However, the forces polarizing Cadherin membrane distribution are not well understood. We previously showed that WAVE-dependent branched actin polarizes Cadherin distribution,… read more here.
Keywords: cadherin transport; media see; transport; recycling endosomes ... See more keywords
Electric field-guided collective motility initiation of large epidermal cell groups.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-09-0391
Abstract: Recent research has elucidated mechanochemical pathways of single cell polarization, but much less is known about collective motility initiation in adhesive cell groups. We used galvanotactic assays of zebrafish keratocyte cell groups, pharmacological perturbations, electric… read more here.
Keywords: electric field; cell; text media; media see ... See more keywords
The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction during Xenopus gastrulation.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-09-0411
Abstract: Apical constriction results in apical surface reduction in epithelial cells and is a widely used mechanism for epithelial morphogenesis. Both medioapical and junctional actomyosin remodeling are involved in apical constriction, but the deployment of medial… read more here.
Keywords: apical constriction; media see; junctional actomyosin; see text ... See more keywords
Outer Arm Dynein Light Chain LC1 Is Required for Normal Motor Assembly Kinetics, Ciliary Stability and Motility.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e23-03-0104
Abstract: Light chain 1 (LC1) is a highly conserved leucine-rich repeat protein associated with the microtubule-binding domain of the Chlamydomonas outer dynein arm γ heavy chain. LC1 mutations in humans and trypanosomes lead to motility defects… read more here.
Keywords: outer arm; arm; media see; see text ... See more keywords